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Information Journal Paper

Title

EFFECT OF ARGININE INFUSION ON GHRELIN SECRETION IN GROWTH HORMONE- SUFFICIENT AND GH-DEFICIENT CHILDREN

Pages

  470-474

Abstract

 Background: The physiological link between ghrelin and GROWTH HORMONE (GH) has not yet been fully clarified. Furthermore, the existence of a negative feedback mechanism between GROWTH HORMONE–insulin-like growth factor (GH–IGF) -I axis and ghrelin and the influence of amino acids on ghrelin secretion in children remain matters of debate.Objectives: To understand the regulation of ghrelin secretion and clarify the relationship between ghrelin and GH secretion in GH-deficient (GHD) and GH-sufficient (GHS) children Patients and Methods: Ten GHD (male/female [M/F], 6/4; age [mean ± SEM], 10.7 ± 0.9 years) and 10 GHS prepubertal children (M/F, 6/4; age [mean ± SEM], 10.3 ± 0.6 years), underwent an arginine (ARG) test (infusion, 0.5 g/kg, iv). Levels of GH, total ghrelin, and ACYLATED GHRELIN (AG) were assayed every 30 min from 0 to+120 min.Results: Peak GH values were lower in GHD subjects than in GHS subjects (P< 0.0001). The baseline levels, peak levels, or area under the curves (AUC) for total ghrelin and AG were similar between GHD and GHS children. ARG infusion was followed by a slight to significant decrease in total ghrelin levels, but not AG levels, both in GHD and GHS subjects with a nadir at+30 min. No correlation was seen between GH, total ghrelin, or AG response and ARG infusion.Conclusions: Total ghrelin and AG levels seemed unaffected by GH status in prepubertal children. ARG infusion was unable to blunt ghrelin secretion irrespective of GH status in childhood. Moreover, since ARG influences GH secretion via modulation of somatostatin release, ghrelin secretion seems to be partially refractory to somatostatin action.

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    APA: Copy

    PRODAM, FLAVIA, GENONI, GIULIA, BELLONE, SIMONETTA, LONGHI, SILVIA, AGARLA, VALENTINA, BONA, GIANNI, & RADETTI, GIORGIO. (2012). EFFECT OF ARGININE INFUSION ON GHRELIN SECRETION IN GROWTH HORMONE- SUFFICIENT AND GH-DEFICIENT CHILDREN. INTERNATIONAL JOURNAL OF ENDOCRINOLOGY AND METABOLISM (IJEM), 10(2), 470-474. SID. https://sid.ir/paper/297441/en

    Vancouver: Copy

    PRODAM FLAVIA, GENONI GIULIA, BELLONE SIMONETTA, LONGHI SILVIA, AGARLA VALENTINA, BONA GIANNI, RADETTI GIORGIO. EFFECT OF ARGININE INFUSION ON GHRELIN SECRETION IN GROWTH HORMONE- SUFFICIENT AND GH-DEFICIENT CHILDREN. INTERNATIONAL JOURNAL OF ENDOCRINOLOGY AND METABOLISM (IJEM)[Internet]. 2012;10(2):470-474. Available from: https://sid.ir/paper/297441/en

    IEEE: Copy

    FLAVIA PRODAM, GIULIA GENONI, SIMONETTA BELLONE, SILVIA LONGHI, VALENTINA AGARLA, GIANNI BONA, and GIORGIO RADETTI, “EFFECT OF ARGININE INFUSION ON GHRELIN SECRETION IN GROWTH HORMONE- SUFFICIENT AND GH-DEFICIENT CHILDREN,” INTERNATIONAL JOURNAL OF ENDOCRINOLOGY AND METABOLISM (IJEM), vol. 10, no. 2, pp. 470–474, 2012, [Online]. Available: https://sid.ir/paper/297441/en

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