IMPACT OF PLASMA GLUCOSE LEVEL AT THE TIME OF FLUOROD EOXYGLUCOSE ADMINISTRATION ON THE ACCURACY OF FDG-PET/CT IN THE DIAGNOSIS OF PANCREATIC LESIONS

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HAMIDIAN JAHROMI ALIREZA; FALLAHZADEH MOHAMMAD KAZEM; TAKALKAR AMOL; SHENG JEAN; ZIBARI GAZI; SHOKOUH AMIRI HOSEIN

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Journal: International Journal of Endocrinology and Metabolism Year:2014 | Volume:12 | Issue:4 Page(s): 1-4

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Title

IMPACT OF PLASMA GLUCOSE LEVEL AT THE TIME OF FLUOROD EOXYGLUCOSE ADMINISTRATION ON THE ACCURACY OF FDG-PET/CT IN THE DIAGNOSIS OF PANCREATIC LESIONS

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Keywords

CANCER

DIAGNOSIS

GLUCOSE

PANCREAS

POSITRON EMISSION TOMOGRAPHY

Abstract

Background: High fasting plasma GLUCOSE (FPG) levels before fluorodeoxyglucose (FDG) administration for POSITRON EMISSION TOMOGRAPHY/computed tomography (PET/CT) might affect the accuracy of 18-fluoro-deoxy-glucose-positron emission tomography-computed tomography (FDG-PET/CT) in DIAGNOSIS of pancreatic lesions. Current guidelines require FPG levels of<200 mg/dL before FDG administration, however, the literature on the effect of FPG levels of<200 mg/dL on the accuracy of FDG-PET/CT is scarce.Objectives: The aim of this study was to evaluate the effect of FPG levels of<200 mg/dL on the accuracy of FDG-PET/CT in DIAGNOSIS of pancreatic lesions.Patients and Methods: In this retrospective study, 161 patients who had FDG-PET/CT for initial DIAGNOSIS of pancreatic lesions were included. Fasting plasma GLUCOSE levels before FDG administration were recorded. Accuracy of FDG-PET/CT in DIAGNOSIS of pancreatic lesions was compared between patients who were normoglycemic (FPG<126 mg/dL) and hyperglycemic (126 £ FPG<200 mg/dL).Results: Thirty-four patients were hyperglycemic and 127 normoglycemic. Sensitivity, specificity, positive predictive value and negative predictive value of FDG-PET/CT were 90%, 88%, 87% and 91% in normoglycemic and 82%, 92%, 95% and 73% in hyperglycemic patients, respectively. Overall, the accuracy was higher in normoglycemic than hyperglycemic patients (89% vs.85%).Conclusions: Accuracy of FDG-PET/CT for primary DIAGNOSIS of pancreatic lesions is higher in patients with FPG levels<126 mg/dL than in patients with FPG levels between 126 and 200 mg/dL.

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APA: Copy

HAMIDIAN JAHROMI, ALIREZA, FALLAHZADEH, MOHAMMAD KAZEM, TAKALKAR, AMOL, SHENG, JEAN, ZIBARI, GAZI, & SHOKOUH AMIRI, HOSEIN. (2014). IMPACT OF PLASMA GLUCOSE LEVEL AT THE TIME OF FLUOROD EOXYGLUCOSE ADMINISTRATION ON THE ACCURACY OF FDG-PET/CT IN THE DIAGNOSIS OF PANCREATIC LESIONS. INTERNATIONAL JOURNAL OF ENDOCRINOLOGY AND METABOLISM (IJEM), 12(4), 1-4. SID. https://sid.ir/paper/297518/en

Vancouver: Copy

HAMIDIAN JAHROMI ALIREZA, FALLAHZADEH MOHAMMAD KAZEM, TAKALKAR AMOL, SHENG JEAN, ZIBARI GAZI, SHOKOUH AMIRI HOSEIN. IMPACT OF PLASMA GLUCOSE LEVEL AT THE TIME OF FLUOROD EOXYGLUCOSE ADMINISTRATION ON THE ACCURACY OF FDG-PET/CT IN THE DIAGNOSIS OF PANCREATIC LESIONS. INTERNATIONAL JOURNAL OF ENDOCRINOLOGY AND METABOLISM (IJEM)[Internet]. 2014;12(4):1-4. Available from: https://sid.ir/paper/297518/en

IEEE: Copy

ALIREZA HAMIDIAN JAHROMI, MOHAMMAD KAZEM FALLAHZADEH, AMOL TAKALKAR, JEAN SHENG, GAZI ZIBARI, and HOSEIN SHOKOUH AMIRI, “IMPACT OF PLASMA GLUCOSE LEVEL AT THE TIME OF FLUOROD EOXYGLUCOSE ADMINISTRATION ON THE ACCURACY OF FDG-PET/CT IN THE DIAGNOSIS OF PANCREATIC LESIONS,” INTERNATIONAL JOURNAL OF ENDOCRINOLOGY AND METABOLISM (IJEM), vol. 12, no. 4, pp. 1–4, 2014, [Online]. Available: https://sid.ir/paper/297518/en

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