ASSOCIATION OF MEAN PLATELET VOLUME WITH ANDROGENS AND INSULIN RESISTANCE IN NONOBESE PATIENTS WITH POLYCYSTIC OVARY SYNDROME

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DOGAN BERCEM AYCICEK; ARDUC AYSE; TUNA MAZHAR MUSLUM; KARAKILIC ERSEN; DAGDELEN IFFET; TUTUNCU YASEMIN; BERKER DILEK; GULER SERDAR

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Journal: International Journal of Endocrinology and Metabolism Year:2014 | Volume:12 | Issue:4 Page(s): 1-5

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Title

ASSOCIATION OF MEAN PLATELET VOLUME WITH ANDROGENS AND INSULIN RESISTANCE IN NONOBESE PATIENTS WITH POLYCYSTIC OVARY SYNDROME

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ANDROGEN HORMONES

MEAN PLATELET VOLUME

POLYCYSTIC OVARY SYNDROME

Abstract

Background: MEAN PLATELET VOLUME (MPV) is generally accepted as a new marker of cardiovascular disease risk in several studies.Objectives: This study aimed to determine the association of MPV with ANDROGEN HORMONES and insulin resistance (IR) in nonobese patients with POLYCYSTIC OVARY SYNDROME (PCOS).Patients and Methods: A total of 136 patients with newly diagnosed reproductive-age PCOS (regarding the criteria of new PCOS phenotypes, based on the Rotterdam criteria) who were nonobese with the mean age of 25 years (25.39 ± 5.51) and mean body mass index (BMI) of 21 kg/m2 (22.07 ± 2.13) were included. In addition, 59 healthy subjects with mean age of 26 years (22.07 ± 2.13) and mean BMI of 22 kg/m2 (21.52 ± 3.84) were recruited as control. Total blood count (including MPV), total testosterone, free testosterone, dehydroepiandrosterone-sulfate (DHEAS), and androstenedione levels were recorded. IR was calculated from blood chemistry measurements of fasting insulin and glucose according to updated homeostasis model assessment.Results: No differences were observed in mean MPV values between patients and control group (9.02 fL (8.5-10.1) and 8.9 fL (7.7-9.1), respectively, P=0.777). MPV values were similar among nonobese patients with and without IR and control subjects (P>0.05). We detected significantly lower values of MPV in patients with hyperandrogenemia in comparison to patients with normal androgen levels (8.7 and 9.5 fL, P=0.012). There was a negative correlation between total testosterone, DHEAS, and MPV (P=0.016, r=-0.229, and P=0.006, r=-0.261, respectively). Multiple logistic regression analyses confirmed the independence of these associations.Conclusions: Our study revealed that nonobese women with and without PCOS have similar MPV values. While IR does not have any effect on MPV, elevated androgen levels are associated with a low MPV in nonobese patients with PCOS.

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APA: Copy

DOGAN, BERCEM AYCICEK, ARDUC, AYSE, TUNA, MAZHAR MUSLUM, KARAKILIC, ERSEN, DAGDELEN, IFFET, TUTUNCU, YASEMIN, BERKER, DILEK, & GULER, SERDAR. (2014). ASSOCIATION OF MEAN PLATELET VOLUME WITH ANDROGENS AND INSULIN RESISTANCE IN NONOBESE PATIENTS WITH POLYCYSTIC OVARY SYNDROME. INTERNATIONAL JOURNAL OF ENDOCRINOLOGY AND METABOLISM (IJEM), 12(4), 1-5. SID. https://sid.ir/paper/297519/en

Vancouver: Copy

DOGAN BERCEM AYCICEK, ARDUC AYSE, TUNA MAZHAR MUSLUM, KARAKILIC ERSEN, DAGDELEN IFFET, TUTUNCU YASEMIN, BERKER DILEK, GULER SERDAR. ASSOCIATION OF MEAN PLATELET VOLUME WITH ANDROGENS AND INSULIN RESISTANCE IN NONOBESE PATIENTS WITH POLYCYSTIC OVARY SYNDROME. INTERNATIONAL JOURNAL OF ENDOCRINOLOGY AND METABOLISM (IJEM)[Internet]. 2014;12(4):1-5. Available from: https://sid.ir/paper/297519/en

IEEE: Copy

BERCEM AYCICEK DOGAN, AYSE ARDUC, MAZHAR MUSLUM TUNA, ERSEN KARAKILIC, IFFET DAGDELEN, YASEMIN TUTUNCU, DILEK BERKER, and SERDAR GULER, “ASSOCIATION OF MEAN PLATELET VOLUME WITH ANDROGENS AND INSULIN RESISTANCE IN NONOBESE PATIENTS WITH POLYCYSTIC OVARY SYNDROME,” INTERNATIONAL JOURNAL OF ENDOCRINOLOGY AND METABOLISM (IJEM), vol. 12, no. 4, pp. 1–5, 2014, [Online]. Available: https://sid.ir/paper/297519/en

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