EFFECT OF INTRANASAL SEDATION USING KETAMINE AND MIDAZOLAM ON BEHAVIOR OF 3-6 YEAR-OLD UNCOOPERATIVE CHILDREN IN DENTAL OFFICE: A CLINICAL TRIAL

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MEHRAN MAJID; TAVASSOLI HOJJATI SARA; AMELI NAZILA; SALEHI ZEINABADI MEHDI

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Journal Paper

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Journal: Frontiers in Dentistry Year:2017 | Volume:14 | Issue:1 Page(s): 1-6

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Title

EFFECT OF INTRANASAL SEDATION USING KETAMINE AND MIDAZOLAM ON BEHAVIOR OF 3-6 YEAR-OLD UNCOOPERATIVE CHILDREN IN DENTAL OFFICE: A CLINICAL TRIAL

Author(s)

MEHRAN MAJID | TAVASSOLI HOJJATI SARA | AMELI NAZILA | SALEHI ZEINABADI MEHDI | Issue Writer Certificate

Keywords

CONSCIOUS SEDATION

KETAMINE

MIDAZOLAM

ADMINISTRATION

INTRANASAL

Abstract

Objectives: The aim of the present study was to compare the effects of INTRANASAL KETAMINE and MIDAZOLAM on behavior of 3-6 year-old children during dental treatments.Materials and Methods: In this randomized cross-over clinical trial, 17 uncooperative children requiring at least two dental treatments were selected and randomly received KETAMINE (0.5mg/kg) or MIDAZOLAM (0.2mg/kg) prior to treatment. The other medication was used in the next visit. The children’s behavioral pattern was determined according to the Houpt's scale regarding sleep, movement, crying and overall behavior. Physiological parameters were also measured at different time intervals. The data were subjected to Wilcoxon Signed Rank test and two-way repeated measures ANOVA.Results: The frequency of crying decreased significantly following KETAMINE ADMINISTRATION compared to MIDAZOLAM (P=0.002); movement of children decreased with fewer incidence of treatment interruption (P=0.001) while their sleepiness increased (P=0.003). Despite higher success of sedation with KETAMINE compared to MIDAZOLAM, no significant differences were found between the two regarding patients’ overall behavior (P>0.05). The patients had higher heart rate and blood pressure with KETAMINE; however, no significant difference was found regarding respiratory rate and oxygen saturation (P>0.05).Conclusions: KETAMINE (0.5mg/kg) led to fewer movements, less crying and more sleepiness compared to MIDAZOLAM (0.2mg/kg). No significant differences were found between the two drugs regarding children’s overall behavior and sedation efficiency. Both drugs demonstrated positive efficacy for sedation of children during dental treatments.

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APA: Copy

MEHRAN, MAJID, TAVASSOLI HOJJATI, SARA, AMELI, NAZILA, & SALEHI ZEINABADI, MEHDI. (2017). EFFECT OF INTRANASAL SEDATION USING KETAMINE AND MIDAZOLAM ON BEHAVIOR OF 3-6 YEAR-OLD UNCOOPERATIVE CHILDREN IN DENTAL OFFICE: A CLINICAL TRIAL. FRONTIERS IN DENTISTRY (JOURNAL OF DENTISTRY OF TEHRAN UNIVERSITY OF MEDICAL SCIENCES), 14(1), 1-6. SID. https://sid.ir/paper/298030/en

Vancouver: Copy

MEHRAN MAJID, TAVASSOLI HOJJATI SARA, AMELI NAZILA, SALEHI ZEINABADI MEHDI. EFFECT OF INTRANASAL SEDATION USING KETAMINE AND MIDAZOLAM ON BEHAVIOR OF 3-6 YEAR-OLD UNCOOPERATIVE CHILDREN IN DENTAL OFFICE: A CLINICAL TRIAL. FRONTIERS IN DENTISTRY (JOURNAL OF DENTISTRY OF TEHRAN UNIVERSITY OF MEDICAL SCIENCES)[Internet]. 2017;14(1):1-6. Available from: https://sid.ir/paper/298030/en

IEEE: Copy

MAJID MEHRAN, SARA TAVASSOLI HOJJATI, NAZILA AMELI, and MEHDI SALEHI ZEINABADI, “EFFECT OF INTRANASAL SEDATION USING KETAMINE AND MIDAZOLAM ON BEHAVIOR OF 3-6 YEAR-OLD UNCOOPERATIVE CHILDREN IN DENTAL OFFICE: A CLINICAL TRIAL,” FRONTIERS IN DENTISTRY (JOURNAL OF DENTISTRY OF TEHRAN UNIVERSITY OF MEDICAL SCIENCES), vol. 14, no. 1, pp. 1–6, 2017, [Online]. Available: https://sid.ir/paper/298030/en

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