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Information Journal Paper

Title

SYNTHESIS AND STUDY OF ANTITUMOR ACTIVITY OF SUBSTITUTED IMIDAZOLECARBOXAMIDES

Pages

  239-244

Abstract

 In view of potential biological activities of small molecule polyamides, we synthesized some novel N-(2-aminoethyl)-1-benzyl-2- (alkylthio)-1H-imidazole-5- carboxamide (7a,b), and N-(2-(1-benzyl-2-(alkylthio) -1H-imidazole- 5-carboxamido) ethyl)-1-benzyl-2- (alkylthio)-1H-imidazole-5-carboxamides (8a,b) as ANTITUMOR agents. The ANTITUMOR activity of compounds 7a,b and 8a,b was studied at concentrations of 0.01, 0.1 and 1 mg/ml, using the potato disk bioassay technique.Vincristine at 0.25 mg/ml employed as positive control and had -67.24% tumor inhibition. Maximum % inhibition for potato tumors was found to be -75.52 for 7b at 1 mg/ml.

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    Cite

    APA: Copy

    HADIZADEH, FARZIN, RAMEZANI, MOHAMMAD, TAYARANI, Z., & EGHBALI, M.. (2007). SYNTHESIS AND STUDY OF ANTITUMOR ACTIVITY OF SUBSTITUTED IMIDAZOLECARBOXAMIDES. IRANIAN JOURNAL OF PHARMACEUTICAL SCIENCES, 3(4), 239-244. SID. https://sid.ir/paper/300224/en

    Vancouver: Copy

    HADIZADEH FARZIN, RAMEZANI MOHAMMAD, TAYARANI Z., EGHBALI M.. SYNTHESIS AND STUDY OF ANTITUMOR ACTIVITY OF SUBSTITUTED IMIDAZOLECARBOXAMIDES. IRANIAN JOURNAL OF PHARMACEUTICAL SCIENCES[Internet]. 2007;3(4):239-244. Available from: https://sid.ir/paper/300224/en

    IEEE: Copy

    FARZIN HADIZADEH, MOHAMMAD RAMEZANI, Z. TAYARANI, and M. EGHBALI, “SYNTHESIS AND STUDY OF ANTITUMOR ACTIVITY OF SUBSTITUTED IMIDAZOLECARBOXAMIDES,” IRANIAN JOURNAL OF PHARMACEUTICAL SCIENCES, vol. 3, no. 4, pp. 239–244, 2007, [Online]. Available: https://sid.ir/paper/300224/en

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