PREDICTION OF SATRANIDAZOLE SOLUBILITY IN WATER-POLYETHYLENE GLYCOL 400 MIXTURES USING EXTENDED HILDEBRAND SOLUBILITY APPROACH

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RATHI PAVAN B.

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Journal: Iranian Journal of Pharmaceutical Sciences Year:2011 | Volume:7 | Issue:1 Page(s): 17-24

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Title

PREDICTION OF SATRANIDAZOLE SOLUBILITY IN WATER-POLYETHYLENE GLYCOL 400 MIXTURES USING EXTENDED HILDEBRAND SOLUBILITY APPROACH

Author(s)

RATHI PAVAN B. | Issue Writer Certificate

Keywords

EXTENDED HILDEBRAND APPROACH

SATRANIDAZOLE

SOLUBILITY PARAMETER

REGULAR SOLUTION THEORY

Abstract

The Extended Hildebrand SOLUBILITY PARAMETER Approach (EHSA) is used to estimate the solubility of SATRANIDAZOLE in binary solvent systems. The solubility of SATRANIDAZOLE in various water-PEG 400 mixtures was analyzed in terms of solutesolvent interactions using a modified version of Hildebrand-Scatchard treatment for regular solutions. The solubility equation employs term interaction energy (W) to replace the geometric mean (d1d2), where d1 and d2 are the cohesive energy densities for the solvent and solute, respectively. The new equation provides an accurate prediction of solubility once the interaction energy ‘W’ is obtained. In this case, the energy term is regressed against a polynomial in d1 of the binary mixture. A quartic expression of ‘W’ in terms of solvent SOLUBILITY PARAMETER was found for predicting the solubility of SATRANIDAZOLE in water-PEG 400 mixtures. The expression yields an error in mole fraction solubility of ~2.17%, a value approximating that of the experimentally determined solubility. The method has potential usefulness in preformulation and formulation studies during which solubility prediction is important for drug design.

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APA: Copy

RATHI, PAVAN B.. (2011). PREDICTION OF SATRANIDAZOLE SOLUBILITY IN WATER-POLYETHYLENE GLYCOL 400 MIXTURES USING EXTENDED HILDEBRAND SOLUBILITY APPROACH. IRANIAN JOURNAL OF PHARMACEUTICAL SCIENCES, 7(1), 17-24. SID. https://sid.ir/paper/300315/en

Vancouver: Copy

RATHI PAVAN B.. PREDICTION OF SATRANIDAZOLE SOLUBILITY IN WATER-POLYETHYLENE GLYCOL 400 MIXTURES USING EXTENDED HILDEBRAND SOLUBILITY APPROACH. IRANIAN JOURNAL OF PHARMACEUTICAL SCIENCES[Internet]. 2011;7(1):17-24. Available from: https://sid.ir/paper/300315/en

IEEE: Copy

PAVAN B. RATHI, “PREDICTION OF SATRANIDAZOLE SOLUBILITY IN WATER-POLYETHYLENE GLYCOL 400 MIXTURES USING EXTENDED HILDEBRAND SOLUBILITY APPROACH,” IRANIAN JOURNAL OF PHARMACEUTICAL SCIENCES, vol. 7, no. 1, pp. 17–24, 2011, [Online]. Available: https://sid.ir/paper/300315/en

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