Green Synthesis and Evaluation of 5-(4-Aminophenyl)-4-Aryl-4H-1, 2, 4-Triazole-3-Thiol Derivatives

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RAJURKAR VIKAS GOPALRAO; Shirsath Sagar M.

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Journal: IRANIAN JOURNAL OF PHARMACEUTICAL SCIENCES Year:2017 | Volume:13 | Issue:2 Page(s): 37-50

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Title

Green Synthesis and Evaluation of 5-(4-Aminophenyl)-4-Aryl-4H-1, 2, 4-Triazole-3-Thiol Derivatives

Author(s)

RAJURKAR VIKAS GOPALRAO | Shirsath Sagar M. | Issue Writer Certificate

Keywords

Triazole

Antimicrobial

MIC

FT-IR

1H-NMR

GC-MS

Abstract

The green synthesis of 5-(4-aminophenyl)-4-aryl-4H-1, 2, 4-Triazole-3-thiol was achieved in four steps. In the first step, 4-amino benzoic acid was refluxed in ethanol along with catalyst Conc. Sulphuric acid to produce ethyl-4-amino benzoate I. Further compound I was refluxed with hydrazine hydrate in ethanol to produce 4-amino benzohydrazide II. Compound II was refluxed in ethanolic potassium hydroxide with carbon disulfide to produce 5-(4-aminophenyl)-1, 3, 4-oxadiazole-2-thiol III. Compound III refluxed in ethanol with different substituted primary aryl amine gave title compounds 5-(4-aminophenyl)-4-aryl-4H-1, 2, 4-Triazole-3-thiol IVa-o. The compounds obtained were identified by FT-IR, 1H-NMR, GC-mass spectroscopy data, and elemental analysis and also screened for in-vivo MICrobial/fa?page=1&sort=1&ftyp=all&fgrp=all&fyrs=all" target="_blank">AntiMICrobial activity. In vitro antibacterial activity was carried out against organisms like E. coli. K. pneumonia, S. aureus, and B. subtilis as well as in vitro antifungal activity were carried out against organisms like A. niger and S. cerevisiae. In vitro MICrobial/fa?page=1&sort=1&ftyp=all&fgrp=all&fyrs=all" target="_blank">AntiMICrobial evaluation, the most potent broad spectrum compound IVc, IVd, and IVf were found significant agent against standard drug Norfloxacin and Ketoconazole.

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APA: Copy

RAJURKAR, VIKAS GOPALRAO, & Shirsath, Sagar M.. (2017). Green Synthesis and Evaluation of 5-(4-Aminophenyl)-4-Aryl-4H-1, 2, 4-Triazole-3-Thiol Derivatives. IRANIAN JOURNAL OF PHARMACEUTICAL SCIENCES, 13(2), 37-50. SID. https://sid.ir/paper/300376/en

Vancouver: Copy

RAJURKAR VIKAS GOPALRAO, Shirsath Sagar M.. Green Synthesis and Evaluation of 5-(4-Aminophenyl)-4-Aryl-4H-1, 2, 4-Triazole-3-Thiol Derivatives. IRANIAN JOURNAL OF PHARMACEUTICAL SCIENCES[Internet]. 2017;13(2):37-50. Available from: https://sid.ir/paper/300376/en

IEEE: Copy

VIKAS GOPALRAO RAJURKAR, and Sagar M. Shirsath, “Green Synthesis and Evaluation of 5-(4-Aminophenyl)-4-Aryl-4H-1, 2, 4-Triazole-3-Thiol Derivatives,” IRANIAN JOURNAL OF PHARMACEUTICAL SCIENCES, vol. 13, no. 2, pp. 37–50, 2017, [Online]. Available: https://sid.ir/paper/300376/en

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