Neuroprotective and Nootropic Activity of Carica Papaya Seeds on Diabetes induced Cognitive Decline in Rats

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Venkateshwarlu Eggadi; Srilatha Keshaveni; Sheshagiri Sharvana Bhava Bandaru; Umasankar Kulandaivelu

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Journal Paper

Paper Information

Journal: IRANIAN JOURNAL OF PHARMACEUTICAL SCIENCES Year:2018 | Volume:14 | Issue:3 Page(s): 107-116

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Title

Neuroprotective and Nootropic Activity of Carica Papaya Seeds on Diabetes induced Cognitive Decline in Rats

Author(s)

Venkateshwarlu Eggadi | Srilatha Keshaveni | Sheshagiri Sharvana Bhava Bandaru | Umasankar Kulandaivelu | Issue Writer Certificate

Keywords

Carica papaya seeds

morris water maze

neuroprotective

nootropic

radial arm maze

cognitive

diabetes

Abstract

The aim of present study is to investigate neuroprotective and nootropic activity of Petroleum Ether Extract of Carica papaya seeds (PEECPS) on diabetic induced cognitive decline rats. Rectangular maze and morris water maze models were used to evaluate nootropic activity and neuroprotective effects were studied by estimating acetyl cholinesterase (AchE), malondialdehyde (MDA), superoxide dismutase (SOD), nitric oxide (NO), catalase (CAT) and glutathione (GSH) levels in the brains of diabetic rats. In rectangular maze and morris water maze models, 400 mg/kg of PECPS were shown the significant effect compared with diabetic control on day 75. Significant decrease in AchE (P<0. 001), MDA (P<0. 01), NO (P<0. 05) and significantly (P<0. 01) increased levels of SOD, CAT and GSH with PECPS (200 and 400 mg/kg) compared with diabetic control. There is a need of further studies on Carica papaya seeds as it showed protection against diabetes induced cognitive decline to reveal its mode of action.

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APA: Copy

Venkateshwarlu, Eggadi, Srilatha, Keshaveni, Sheshagiri Sharvana Bhava, Bandaru, & Umasankar, Kulandaivelu. (2018). Neuroprotective and Nootropic Activity of Carica Papaya Seeds on Diabetes induced Cognitive Decline in Rats. IRANIAN JOURNAL OF PHARMACEUTICAL SCIENCES, 14(3), 107-116. SID. https://sid.ir/paper/300397/en

Vancouver: Copy

Venkateshwarlu Eggadi, Srilatha Keshaveni, Sheshagiri Sharvana Bhava Bandaru, Umasankar Kulandaivelu. Neuroprotective and Nootropic Activity of Carica Papaya Seeds on Diabetes induced Cognitive Decline in Rats. IRANIAN JOURNAL OF PHARMACEUTICAL SCIENCES[Internet]. 2018;14(3):107-116. Available from: https://sid.ir/paper/300397/en

IEEE: Copy

Eggadi Venkateshwarlu, Keshaveni Srilatha, Bandaru Sheshagiri Sharvana Bhava, and Kulandaivelu Umasankar, “Neuroprotective and Nootropic Activity of Carica Papaya Seeds on Diabetes induced Cognitive Decline in Rats,” IRANIAN JOURNAL OF PHARMACEUTICAL SCIENCES, vol. 14, no. 3, pp. 107–116, 2018, [Online]. Available: https://sid.ir/paper/300397/en

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