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Information Journal Paper

Title

Protective Effects of Pioglitazone on Dextran Sodium Sulphate-Induced Colitis in Rats

Pages

  1-12

Abstract

 The aim of the present study is to investigate the preventive effect of Pioglitazone on Colitis induced with dextran sulfate sodium (DSS) in Rats. Twenty-four male Sprague-Dawley Rats weighing 180-200 g were randomized into four groups. Rats of the 1st group received only saline and served as normal group. Colitis was induced in the remaining 3 groups by 1. 5% DSS administered in drinking water for 8 days. Group 2 received only saline p. o. for 30 days and served as DSS control group. Groups 3 and 4 received Pioglitazone (PIO; 10 mg/kg/day, p. o. ) and sulfasalazine (SUL; 300 mg/kg) respectively for 30 days. All animals were sacrificed 24 h after the last treatment. Serum levels of interleukin-2 (IL-2), Interleukin-6 (IL-6), and interleukin-17 (IL-17) were measured. Levels of tumor necrosis factor-α (TNF-α ), reduced glutathione (GSH) and malondialdhyde (MDA), were measured in colon tissue. Significant elevation in GSH levels and reduction in MDA and TNF-α levels in colon tissue were observed in Pioglitazone and sulfasalazine treated group when compared with the DSS control group. Significant elevation in serum IL-2 and reduction in serum IL-6 and IL-17 were observed when compared with the DSS control group. Pioglitazone reduced DSS-induced Colitis possibly via reduction of MDA, TNF-α , IL-6, and IL-17 levels.

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    APA: Copy

    El Awdan, Sally, & Mostafa, Rasha E.. (2018). Protective Effects of Pioglitazone on Dextran Sodium Sulphate-Induced Colitis in Rats. IRANIAN JOURNAL OF PHARMACEUTICAL SCIENCES, 14(3), 1-12. SID. https://sid.ir/paper/300402/en

    Vancouver: Copy

    El Awdan Sally, Mostafa Rasha E.. Protective Effects of Pioglitazone on Dextran Sodium Sulphate-Induced Colitis in Rats. IRANIAN JOURNAL OF PHARMACEUTICAL SCIENCES[Internet]. 2018;14(3):1-12. Available from: https://sid.ir/paper/300402/en

    IEEE: Copy

    Sally El Awdan, and Rasha E. Mostafa, “Protective Effects of Pioglitazone on Dextran Sodium Sulphate-Induced Colitis in Rats,” IRANIAN JOURNAL OF PHARMACEUTICAL SCIENCES, vol. 14, no. 3, pp. 1–12, 2018, [Online]. Available: https://sid.ir/paper/300402/en

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