مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

video

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

sound

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Persian Version

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

View:

163
مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Download:

91
مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Cites:

Information Journal Paper

Title

Thrombolytic, Membrane stabilizing, Antidiarrhoeal, and Antimicrobial Properties of Bioactive Compounds Isolated from leaves of Sesbania grandiflora Naturally Growing in Bangladesh

Pages

  31-46

Abstract

 Sesbania grandiflora leaves are extensively used locally since ancient time as in traditional systems. Based on mainly folkloric use, we investigated to know the potential of Sesbania grandiflora leaves extracts through biological works in vivo and in vitro. The ethanolic extract of S. grandiflora leaves was partitioned into ethyl acetate soluble fraction (ESF), petroleum ether soluble fraction (PSF), carbon tetrachloride soluble fraction (CTSF), chloroform soluble fraction (CSF), and aqueous soluble fraction (AQSF). The extracts were evaluated for their thrombolytic, membrane stabilizing, antimicrobial and antidiarrhoeal activities and the results were compared with standard drugs; streptokinase for thrombolytic, acetyl salicylic acid for anti-inflammatory, kanamycin for antimicrobial activities and loperamide against diarrhoea. In thrombolytic investigation, among all partitionates, the ESF showed highest % of clot lysis (59. 57%) as compared to (69. 23%) and (3. 07%) exhibited by the standard streptokinase and water. In case of membrane stabilizing study, ESF also significantly inhibited the haemolysis of human erythrocyte membrane both induced by hypotonic solution (64. 30 ± 0. 64%) and by heat (57. 21 ± 0. 69%), respectively as compared to (70. 12 ± 26%) and (73. 90 ± 0. 29%) demonstrated by acetyl salicylic acid. In the antidiarrhoeal assay, the ethanolic extract (EE) inhibited the mean number of defecation by 24. 97% and 41. 05% at 200 mg/kg and 400 mg/kg body weight, respectively. In antibacterial activity, it was exhibited by the extracts being comparatively more prominent on the gram negative bacteria than the gram positive bacteria. Our study revealed that satisfactory amount of flavonoid and tannin presence showed a significant and positive correlation between total phenolic compound contents with pharmacological activities of S. grandiflora

Cites

  • No record.

    • References

  • No record.

    • Cite

    APA: Copy

    Arfan, Nafisa Binte, Islam, Torikul, Sultana Julie, Azima, Mohiuddin, AK, Alam Khan, Shah, & Labu, Zubair Khalid. (2016). Thrombolytic, Membrane stabilizing, Antidiarrhoeal, and Antimicrobial Properties of Bioactive Compounds Isolated from leaves of Sesbania grandiflora Naturally Growing in Bangladesh. IRANIAN JOURNAL OF PHARMACEUTICAL SCIENCES, 12(3), 31-46. SID. https://sid.ir/paper/300422/en

    Vancouver: Copy

    Arfan Nafisa Binte, Islam Torikul, Sultana Julie Azima, Mohiuddin AK, Alam Khan Shah, Labu Zubair Khalid. Thrombolytic, Membrane stabilizing, Antidiarrhoeal, and Antimicrobial Properties of Bioactive Compounds Isolated from leaves of Sesbania grandiflora Naturally Growing in Bangladesh. IRANIAN JOURNAL OF PHARMACEUTICAL SCIENCES[Internet]. 2016;12(3):31-46. Available from: https://sid.ir/paper/300422/en

    IEEE: Copy

    Nafisa Binte Arfan, Torikul Islam, Azima Sultana Julie, AK Mohiuddin, Shah Alam Khan, and Zubair Khalid Labu, “Thrombolytic, Membrane stabilizing, Antidiarrhoeal, and Antimicrobial Properties of Bioactive Compounds Isolated from leaves of Sesbania grandiflora Naturally Growing in Bangladesh,” IRANIAN JOURNAL OF PHARMACEUTICAL SCIENCES, vol. 12, no. 3, pp. 31–46, 2016, [Online]. Available: https://sid.ir/paper/300422/en

    Related Journal Papers

  • No record.

    • Related Seminar Papers

  • No record.

    • Related Plans

  • No record.

    • Recommended Workshops






    Move to top
    telegram sharing button
    whatsapp sharing button
    linkedin sharing button
    twitter sharing button
    email sharing button
    email sharing button
    email sharing button
    sharethis sharing button