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Information Journal Paper

Title

Short Communication: The Effect of Various Stabilizers on Preserving Immunogenicity of Lyophilized Mumps Vaccines

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  0-0

Abstract

 Background: Chemical stabilizers are added to live attenuated Vaccines for enhancing the virus stability. The aim of this study was to evaluate the effect of various stabilizers on preserving Immunogenicity of lyophilized mumps Vaccines. Study design: An experimental study. Methods: Three mumps Vaccines with different formulations were inoculated to three groups of Guinea pigs. Sterile water was injected to eight Guinea pigs as a control group. Blood samples were collected before inoculation and on 14, 28 and 42 d after Vaccine injection. Mumps antibodies in the sera were measured using hemagglutination inhibition assay (HAI). Results: All three formulated mumps Vaccines induced antibody in Guinea pigs after two weeks. Formulation 1 containing trehalose dihydrate and formulation 2 comprised human serum albumin stimulated antibodies in the higher level than Razi routine formulation. Conclusions: Various stabilizers have different preservation potencies that differently affect immune response against virus. More stable and more immunogenic Vaccines can be produced using stabilizers containing trehalose dihydrate.

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    APA: Copy

    Kamali Jamil, Razieh, SHAYESTEHPOUR, MOHAMMAD, SADIGH, ZOHREH AZITA, Taqavian, Mohammad, SHAHKARAMI, MOHAMMAD KAZEM, ESNA ASHARI, FATEMEH, SHAHBAZI, REZA, MOHAMMADI, ASHRAF, Foroughi, Abolhasan, & Romani, Bizhan. (2017). Short Communication: The Effect of Various Stabilizers on Preserving Immunogenicity of Lyophilized Mumps Vaccines. JOURNAL OF RESEARCH IN HEALTH SCIENCES (JRHS), 17(4), 0-0. SID. https://sid.ir/paper/301642/en

    Vancouver: Copy

    Kamali Jamil Razieh, SHAYESTEHPOUR MOHAMMAD, SADIGH ZOHREH AZITA, Taqavian Mohammad, SHAHKARAMI MOHAMMAD KAZEM, ESNA ASHARI FATEMEH, SHAHBAZI REZA, MOHAMMADI ASHRAF, Foroughi Abolhasan, Romani Bizhan. Short Communication: The Effect of Various Stabilizers on Preserving Immunogenicity of Lyophilized Mumps Vaccines. JOURNAL OF RESEARCH IN HEALTH SCIENCES (JRHS)[Internet]. 2017;17(4):0-0. Available from: https://sid.ir/paper/301642/en

    IEEE: Copy

    Razieh Kamali Jamil, MOHAMMAD SHAYESTEHPOUR, ZOHREH AZITA SADIGH, Mohammad Taqavian, MOHAMMAD KAZEM SHAHKARAMI, FATEMEH ESNA ASHARI, REZA SHAHBAZI, ASHRAF MOHAMMADI, Abolhasan Foroughi, and Bizhan Romani, “Short Communication: The Effect of Various Stabilizers on Preserving Immunogenicity of Lyophilized Mumps Vaccines,” JOURNAL OF RESEARCH IN HEALTH SCIENCES (JRHS), vol. 17, no. 4, pp. 0–0, 2017, [Online]. Available: https://sid.ir/paper/301642/en

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