Exposure Assessment, Biological Monitoring, and Liver Function Tests of Operating Room Personnel Exposed to Halothane in Hamedan Hospitals, West of Iran

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

Bakhshaei Mohammad Hossien; BAHRAMI ABDULRAHMAN; Mirzakhani Amin; Mahjub Hossien; ASSARI MOHAMMAD JAVAD

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: JOURNAL OF RESEARCH IN HEALTH SCIENCES (JRHS) Year:2017 | Volume:17 | Issue:4 Page(s): 0-0

Download Full-Text

View:

417

Download:

155

Cites:

Information Journal Paper

Title

Exposure Assessment, Biological Monitoring, and Liver Function Tests of Operating Room Personnel Exposed to Halothane in Hamedan Hospitals, West of Iran

Author(s)

Keywords

Halothane

Aspartate

Aminotransferase

Alanine Aminotransferase

Bromides

Anesthesia

Abstract

Background: Occupational exposure to halogenated hydrocarbons has been associated with Halothane hepatitis, an increase of liver enzymes, and congenital malformations. The objectives of this study were to investigate whether bromide, a urinary metabolite of Halothane, could be used as a biological marker of exposure to this anesthetic gas and assessment of associated exposure to Halothane with any significant changes in conventional parameters of liver function (serum Aminotransferase activities). Study design: A cross-sectional study. Methods: Seventy-five anesthesiologists, Anesthesia nurses, operating room nurses, and surgeons (exposed group) and 75 matched unexposed individuals (reference group) were selected randomly from two public hospitals in Hamadan City, west of Iran. Atmospheric concentrations of Halothane in the breathing zone of the exposed subjects and urinary bromide levels were measured by headspace gas chromatography. Similarly, serum activities of alanine Aminotransferase (ALT) and Aspartate Aminotransferase (AST) were measured by the enzymatic method using an automatic Prestige instrument. Results: Mean atmospheric concentrations of Halothane and urinary bromide levels for exposed subjects were 1. 49 ± 1. 36 ppm and 0. 83 ± 0. 29 mM, respectively. A relatively good correlation was found between exposure to Halothane and urinary bromide levels (r=0. 38). The chi-squared test results showed that the proportions of the subjects with abnormal ALT and AST among the women exposed were significantly higher than those of reference individuals (P<0. 05). Conclusions: Urinary bromide can be used as a potential biomarker of exposure to Halothane, although additional studies are necessary to further validate these initial findings.

Cites

No record.

References

No record.

Cite

APA: Copy

Bakhshaei, Mohammad Hossien, BAHRAMI, ABDULRAHMAN, Mirzakhani, Amin, Mahjub, Hossien, & ASSARI, MOHAMMAD JAVAD. (2017). Exposure Assessment, Biological Monitoring, and Liver Function Tests of Operating Room Personnel Exposed to Halothane in Hamedan Hospitals, West of Iran. JOURNAL OF RESEARCH IN HEALTH SCIENCES (JRHS), 17(4), 0-0. SID. https://sid.ir/paper/301644/en

Vancouver: Copy

Bakhshaei Mohammad Hossien, BAHRAMI ABDULRAHMAN, Mirzakhani Amin, Mahjub Hossien, ASSARI MOHAMMAD JAVAD. Exposure Assessment, Biological Monitoring, and Liver Function Tests of Operating Room Personnel Exposed to Halothane in Hamedan Hospitals, West of Iran. JOURNAL OF RESEARCH IN HEALTH SCIENCES (JRHS)[Internet]. 2017;17(4):0-0. Available from: https://sid.ir/paper/301644/en

IEEE: Copy

Mohammad Hossien Bakhshaei, ABDULRAHMAN BAHRAMI, Amin Mirzakhani, Hossien Mahjub, and MOHAMMAD JAVAD ASSARI, “Exposure Assessment, Biological Monitoring, and Liver Function Tests of Operating Room Personnel Exposed to Halothane in Hamedan Hospitals, West of Iran,” JOURNAL OF RESEARCH IN HEALTH SCIENCES (JRHS), vol. 17, no. 4, pp. 0–0, 2017, [Online]. Available: https://sid.ir/paper/301644/en

Related Journal Papers

No record.

Related Seminar Papers

No record.

Related Plans

No record.

Recommended Workshops