EVALUATING THE CORRELATION BETWEEN SERUM NT-PRO BNP LEVEL AND DIASTOLIC DYSFUNCTION SEVERITY IN BETA- THALASSEMIA MAJOR PATIENTS

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ALIZADEH BEHZAD; BADIEE ZAHRA; MAHMOUDI MAHMOUD; MOHAJERY MAHSA

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Journal: THE JOURNAL OF TEHRAN UNIVERSITY HEART CENTER Year:2016 | Volume:11 | Issue:2 Page(s): 68-72

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Title

EVALUATING THE CORRELATION BETWEEN SERUM NT-PRO BNP LEVEL AND DIASTOLIC DYSFUNCTION SEVERITY IN BETA- THALASSEMIA MAJOR PATIENTS

Author(s)

ALIZADEH BEHZAD | BADIEE ZAHRA | MAHMOUDI MAHMOUD | MOHAJERY MAHSA | Issue Writer Certificate

Keywords

BETA-THALASSEMIA

PRO-BRAIN NATRIURETIC PEPTIDE

VENTRICULAR DYSFUNCTION

LEFT

Abstract

Background: N-terminal PRO-BRAIN NATRIURETIC PEPTIDE (NT-proBNP) is a sensitive biomarker for the detection of asymptomatic LEFT ventricular (LV) dysfunction. Since b-thalassemia major patients suffer from early diastolic dysfunction due to iron deposition of chronic blood transfusion, we tried to evaluate the correlation between the serum NT-proBNP level and the severity of LV diastolic dysfunction determined by echocardiography in these patients.Methods: Fifty b-thalassemia major patients with normal LV systolic function were studied by tissue Doppler echocardiography, and blood samples were taken at the same time to measure the serum NT-proBNP level. Using flow velocity through the mitral valve on the tissue velocity of the mitral annulus in early ventricular filling (E/E’) as an LV diastolic function indicator, the patients were divided into 3 groups: group 1) no diastolic dysfunction (E/E’<8), group 2) suspected diastolic dysfunction (E/E' =8-15), and group 3) documented diastolic dysfunction (E/E’>15). Other variables assessed included sex, age, method of chelator therapy, and mean hemoglobin and ferritin levels for the past 2 years.Results: According to the echocardiographic findings of all the 50 patients (29 male and 21 female) with an age range of 11-35 years (mean=17.98 y), 46% were classified in group 1, 54% in group 2, and none in group 3. The NT-proBNP level was 1070 ± 566 ng/mL in group 1 and 974 ± 515 ng/mL in group 2. The t-test showed no significant difference between groups 1 and 2 in the NT-proBNP level (p value=0.536).Conclusion: Due to specific conditions in thalassemia major patients, the correlation between the serum NT-proBNP level and the severity of diastolic dysfunction seems to be not meaningful.

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APA: Copy

ALIZADEH, BEHZAD, BADIEE, ZAHRA, MAHMOUDI, MAHMOUD, & MOHAJERY, MAHSA. (2016). EVALUATING THE CORRELATION BETWEEN SERUM NT-PRO BNP LEVEL AND DIASTOLIC DYSFUNCTION SEVERITY IN BETA- THALASSEMIA MAJOR PATIENTS. THE JOURNAL OF TEHRAN UNIVERSITY HEART CENTER, 11(2), 68-72. SID. https://sid.ir/paper/302041/en

Vancouver: Copy

ALIZADEH BEHZAD, BADIEE ZAHRA, MAHMOUDI MAHMOUD, MOHAJERY MAHSA. EVALUATING THE CORRELATION BETWEEN SERUM NT-PRO BNP LEVEL AND DIASTOLIC DYSFUNCTION SEVERITY IN BETA- THALASSEMIA MAJOR PATIENTS. THE JOURNAL OF TEHRAN UNIVERSITY HEART CENTER[Internet]. 2016;11(2):68-72. Available from: https://sid.ir/paper/302041/en

IEEE: Copy

BEHZAD ALIZADEH, ZAHRA BADIEE, MAHMOUD MAHMOUDI, and MAHSA MOHAJERY, “EVALUATING THE CORRELATION BETWEEN SERUM NT-PRO BNP LEVEL AND DIASTOLIC DYSFUNCTION SEVERITY IN BETA- THALASSEMIA MAJOR PATIENTS,” THE JOURNAL OF TEHRAN UNIVERSITY HEART CENTER, vol. 11, no. 2, pp. 68–72, 2016, [Online]. Available: https://sid.ir/paper/302041/en

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