EFFECTS OF ESTROGEN RECEPTOR MODULATORS ON MORPHINE INDUCED SENSITIZATION IN MICE MEMORY

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ANOUSH MAHDIEH; JANI ALI; SAHEBGHARANI MOOSA; JAFARI MOHAMMAD REZA

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Journal Paper

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Journal: Iranian Journal of Psychiatry Year:2015 | Volume:10 | Issue:3 Page(s): 192-199

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Title

EFFECTS OF ESTROGEN RECEPTOR MODULATORS ON MORPHINE INDUCED SENSITIZATION IN MICE MEMORY

Author(s)

ANOUSH MAHDIEH | JANI ALI | SAHEBGHARANI MOOSA | JAFARI MOHAMMAD REZA | Issue Writer Certificate

Keywords

ESTRADIOL VALERATE

RALOXIFENE

STEP-DOWN

SENSITIZATION

MEMORY

OPIOIDS

Abstract

Objective: In this study, the effects of ESTRADIOL VALERATE and RALOXIFENEa selective estrogen receptor modulator; (SERM) on morphine induced SENSITIZATION were examined in mice MEMORY, according to the STEP-DOWN passive avoidance task.Method: The mice received morphine or estradiol and RALOXIFENE for three days alone or in combination with morphine. After a drug free period of 5 days, the subjects received saline or morphine as pre- training treatments followed by a pre-test saline administration. The MEMORY retrieval was evaluated using STEP-DOWN passive avoidance test both on the training and test day.Results: The results illustrated that the three- day administration of morphine induced SENSITIZATION through the enhancement of MEMORY retrieval (morphine induced SENSITIZATION in mice MEMORY). Both the three- day administration of ESTRADIOL VALERATE alone and with morphine (5 mg/kg) restored MEMORY. On the other hand, the three- day administration of RALOXIFENE had no effect on MEMORY retrieval alone, but declined morphine induced SENSITIZATION in mice MEMORY.Conclusion: The results of the study indicated that there is an interaction between estrogen receptor modulators and morphine induced SENSITIZATION in mice MEMORY.

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APA: Copy

ANOUSH, MAHDIEH, JANI, ALI, SAHEBGHARANI, MOOSA, & JAFARI, MOHAMMAD REZA. (2015). EFFECTS OF ESTROGEN RECEPTOR MODULATORS ON MORPHINE INDUCED SENSITIZATION IN MICE MEMORY. IRANIAN JOURNAL OF PSYCHIATRY, 10(3), 192-199. SID. https://sid.ir/paper/302371/en

Vancouver: Copy

ANOUSH MAHDIEH, JANI ALI, SAHEBGHARANI MOOSA, JAFARI MOHAMMAD REZA. EFFECTS OF ESTROGEN RECEPTOR MODULATORS ON MORPHINE INDUCED SENSITIZATION IN MICE MEMORY. IRANIAN JOURNAL OF PSYCHIATRY[Internet]. 2015;10(3):192-199. Available from: https://sid.ir/paper/302371/en

IEEE: Copy

MAHDIEH ANOUSH, ALI JANI, MOOSA SAHEBGHARANI, and MOHAMMAD REZA JAFARI, “EFFECTS OF ESTROGEN RECEPTOR MODULATORS ON MORPHINE INDUCED SENSITIZATION IN MICE MEMORY,” IRANIAN JOURNAL OF PSYCHIATRY, vol. 10, no. 3, pp. 192–199, 2015, [Online]. Available: https://sid.ir/paper/302371/en

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