Impact of Exposure to Environmental Enrichment on the Anxiety-Like Behavior of Ovariectomized Mice

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Briones Aranda Alfredo; Castellanos Perez Manuela; Vega Villa Victor Manuel; Picazo Ofir

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Journal: Iranian Journal of Psychiatry Year:2020 | Volume:15 | Issue:1 Page(s): 88-95

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Title

Impact of Exposure to Environmental Enrichment on the Anxiety-Like Behavior of Ovariectomized Mice

Author(s)

Briones Aranda Alfredo | Castellanos Perez Manuela | Vega Villa Victor Manuel | Picazo Ofir | Issue Writer Certificate

Keywords

Anxiety-Like Behavior

Ovariectomized Mice

Physical Enrichment

Social Enrichment

Abstract

Objective: The aim of this study was to explore the influence of short-term (2-week) exposure to social (SE) and/or Physical Enrichment (PE) on the Anxiety-Like Behavior of ovariectomized (OVX) NIH Swiss mice. Method: One week after surgery, each OVX mouse was housed under one of 4 social conditions: (1) isolated, (2) accompanied by an intact female, (3) accompanied by an intact male, or (4) in a community of 10 OVX individuals. The animals in each of these environments were divided into 2 subgroups, consisting of the presence and absence of PE. Following a 2-week exposure to the respective conditions, each OVX mouse was subjected to either the light/dark exploration test (LDT) or the elevated plus maze (EPM) to examine Anxiety-Like Behavior. Results: The LDT and EPM showed very similar patterns. Compared to an impoverished environment, PE elicited a significant anxiolytic effect for OVX mice housed alone or in companion of an intact female (F [1, 54] = 16. 11, P = 0. 001). By contrast, mice living in community but without PE displayed anxiogenic-like behavior, perhaps due to crowding, compared to the animals living in isolation (F [1, 36] = 5. 64, P = 0. 023). Conclusion: This study emphasized the importance of taking housing conditions into account during the screening of new anxiolytic agents and the critical role of OVX in the regulation of anxiety.

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APA: Copy

Briones Aranda, Alfredo, Castellanos Perez, Manuela, Vega Villa, Victor Manuel, & Picazo, Ofir. (2020). Impact of Exposure to Environmental Enrichment on the Anxiety-Like Behavior of Ovariectomized Mice. IRANIAN JOURNAL OF PSYCHIATRY, 15(1), 88-95. SID. https://sid.ir/paper/302491/en

Vancouver: Copy

Briones Aranda Alfredo, Castellanos Perez Manuela, Vega Villa Victor Manuel, Picazo Ofir. Impact of Exposure to Environmental Enrichment on the Anxiety-Like Behavior of Ovariectomized Mice. IRANIAN JOURNAL OF PSYCHIATRY[Internet]. 2020;15(1):88-95. Available from: https://sid.ir/paper/302491/en

IEEE: Copy

Alfredo Briones Aranda, Manuela Castellanos Perez, Victor Manuel Vega Villa, and Ofir Picazo, “Impact of Exposure to Environmental Enrichment on the Anxiety-Like Behavior of Ovariectomized Mice,” IRANIAN JOURNAL OF PSYCHIATRY, vol. 15, no. 1, pp. 88–95, 2020, [Online]. Available: https://sid.ir/paper/302491/en

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