ACCIDENTAL CHILDREN POISONING WITH METHADONE: AN IRANIAN PEDIATRIC SECTIONAL STUDY

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JABBEHDARI SAYENA; FARNAGHI FARIBA; SEYED FAKHREDDIN SHARIATMADARI; JAFARI NARJES; FERESHTEH MEHREGAN FATEMEH; KARIMZADEH PARVANEH

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Journal: Iranian Journal of Child Neurology Year:2013 | Volume:7 | Issue:4 Page(s): 32-34

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Title

ACCIDENTAL CHILDREN POISONING WITH METHADONE: AN IRANIAN PEDIATRIC SECTIONAL STUDY

Author(s)

Keywords

CHILDREN

OPIUM

METHADONE

POISONING SAYENA

Abstract

Objective toxic poisoning with METHADONE is common in CHILDREN in Iran. Our study was carried out due to the changing pattern of METHADONE poisoning in recent years and increasing METHADONE toxicity.Materials&Methods In this descriptive-sectional study, all of the METHADONE poisoned CHILDREN younger than 12 years who were admitted to the Loghman Hakim Hospital in 2012, were assessed. Clinical symptoms and signs, para-clinical findings, and treatment were evaluated.Results In this study, 16 boys and 15 girls who had been poisoned by METHADONE were enrolled. The mean age of patients was 55 months. All patients had been poisoned randomly or due to parent’s mistakes. The mean time of symptoms onset after METHADONE consumption was 1 hour and 30 Min, indicating a relatively long time after onset of symptoms.Clinical findings were drowsiness (75%), miotic pupil (68 %), vomiting (61%), rapid shallow breathing (57%) and apnea (40%). In paraclinical tests, respiratory acidosis (69%) and leukocytosis (55.2%) were seen. The most important finding was increase in distance of QT in ECG (23.8%). The mean time of treatment with naloxone infusion was 51 hours. Three percent of patients had a return of symptoms after discontinuation of METHADONE. In patients with apnea, a longer course of treatment was required, and this difference was significant. Also, 17% of patients with apnea had aspiration pneumonia, which was statistically significant.Conclusion We suggest long time treatment with naloxone and considering the probability of return of symptoms after discontinuation of METHADONE.

Cites

Stress Cardiomyopathy (Takotsubo syndrome) Following Accidental Methadone Poisoning; Report of Two Pediatric Cases

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APA: Copy

JABBEHDARI, SAYENA, FARNAGHI, FARIBA, SEYED FAKHREDDIN, SHARIATMADARI, JAFARI, NARJES, FERESHTEH MEHREGAN, FATEMEH, & KARIMZADEH, PARVANEH. (2013). ACCIDENTAL CHILDREN POISONING WITH METHADONE: AN IRANIAN PEDIATRIC SECTIONAL STUDY. IRANIAN JOURNAL OF CHILD NEUROLOGY (IJCN), 7(4), 32-34. SID. https://sid.ir/paper/303390/en

Vancouver: Copy

JABBEHDARI SAYENA, FARNAGHI FARIBA, SEYED FAKHREDDIN SHARIATMADARI, JAFARI NARJES, FERESHTEH MEHREGAN FATEMEH, KARIMZADEH PARVANEH. ACCIDENTAL CHILDREN POISONING WITH METHADONE: AN IRANIAN PEDIATRIC SECTIONAL STUDY. IRANIAN JOURNAL OF CHILD NEUROLOGY (IJCN)[Internet]. 2013;7(4):32-34. Available from: https://sid.ir/paper/303390/en

IEEE: Copy

SAYENA JABBEHDARI, FARIBA FARNAGHI, SHARIATMADARI SEYED FAKHREDDIN, NARJES JAFARI, FATEMEH FERESHTEH MEHREGAN, and PARVANEH KARIMZADEH, “ACCIDENTAL CHILDREN POISONING WITH METHADONE: AN IRANIAN PEDIATRIC SECTIONAL STUDY,” IRANIAN JOURNAL OF CHILD NEUROLOGY (IJCN), vol. 7, no. 4, pp. 32–34, 2013, [Online]. Available: https://sid.ir/paper/303390/en

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