CNS STRUCTURAL ANOMALIES IN IRANIAN CHILDREN WITH GLOBAL DEVELOPMENTAL DELAY

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ZAMANI GHOLAM REZA; SHERVIN BADV REZA; NIKSIRAT ALI; ALIZADEH HOUMAN

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Journal Paper

Paper Information

Journal: Iranian Journal of Child Neurology Year:2013 | Volume:7 | Issue:1 Page(s): 25-28

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Title

CNS STRUCTURAL ANOMALIES IN IRANIAN CHILDREN WITH GLOBAL DEVELOPMENTAL DELAY

Author(s)

ZAMANI GHOLAM REZA | SHERVIN BADV REZA | NIKSIRAT ALI | ALIZADEH HOUMAN | Issue Writer Certificate

Keywords

DEVELOPMENTAL DELAY

CNS DEVELOPMENTAL ANOMALIES

ETIOLOGY

NEUROIMAGING

Abstract

Objective:Central Nervous system (CNS) malformations are one of the most important causes of global DEVELOPMENTAL DELAY (GDD) in Children. About one percent of infants with GDD have an inherited metabolic disorder and 3-10 percent ave a chromosomal disorder. This study aimed to survey the frequency of brain structural anomalies and their subtypes among the variety of etiologic factors in children with GDD in our patients.Materials d Methods:This study used the results of NEUROIMAGING studies [unenhanced brain Magnetic Resonance Imaging (MRI)] of all children who had been referred for evaluation of GDD to outpatient Clinic of Pediatric neurology at Children’s Medical Center affiliated to Tehran University of Medical Science between September 2009 and September 2010.Results:In this study, unenhanced brain MRI was performed on 405 children, of which 80 cases (20 percent) had brain structural anomalies. In 8.7 percent of the cases, previous history of brain structural disorders existed in other children of the family and 20 percent of mothers had inadequate consumption of folate during pregnancy.Conclusion:Based on the results of this study, unenhanced cranial MRI seems to be a fundamental part of evaluation in all children with GDD. Adequate folate consumption as prophylaxis as well as genetic counseling can be worthy for high-risk mothers who have previous history of CNS anomaly or miscarriage to avoid repeated CNS anomalies in their next pregnancies.

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APA: Copy

ZAMANI, GHOLAM REZA, SHERVIN BADV, REZA, NIKSIRAT, ALI, & ALIZADEH, HOUMAN. (2013). CNS STRUCTURAL ANOMALIES IN IRANIAN CHILDREN WITH GLOBAL DEVELOPMENTAL DELAY. IRANIAN JOURNAL OF CHILD NEUROLOGY (IJCN), 7(1), 25-28. SID. https://sid.ir/paper/303426/en

Vancouver: Copy

ZAMANI GHOLAM REZA, SHERVIN BADV REZA, NIKSIRAT ALI, ALIZADEH HOUMAN. CNS STRUCTURAL ANOMALIES IN IRANIAN CHILDREN WITH GLOBAL DEVELOPMENTAL DELAY. IRANIAN JOURNAL OF CHILD NEUROLOGY (IJCN)[Internet]. 2013;7(1):25-28. Available from: https://sid.ir/paper/303426/en

IEEE: Copy

GHOLAM REZA ZAMANI, REZA SHERVIN BADV, ALI NIKSIRAT, and HOUMAN ALIZADEH, “CNS STRUCTURAL ANOMALIES IN IRANIAN CHILDREN WITH GLOBAL DEVELOPMENTAL DELAY,” IRANIAN JOURNAL OF CHILD NEUROLOGY (IJCN), vol. 7, no. 1, pp. 25–28, 2013, [Online]. Available: https://sid.ir/paper/303426/en

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