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Information Journal Paper

Title

PLASMA PYRIDOXAL 5'-PHOSPHATE LEVEL IN CHILDREN WITH INTRACTABLE AND CONTROLLED EPILEPSY

Pages

  31-36

Abstract

 ObjectiveIntractable epilepsy is a serious neurologic problem with different etiologies.Decreased levels of pyridoxal phosphate in cerebral spinal fluid of patientswith INTRACTABLE EPILEPSY due to pyridoxine dependency epilepsy are reported.The aim of this study was to compare plasma pyridoxal 5’-phosphate level inpatients with intractable and controlled epilepsy.Materials & MethodsThis cross- sectional analytic study included 66 epileptic CHILDREN, 33 patientswith controlled and 33 patients with INTRACTABLE EPILEPSY, after neonatal periodup to 15 yr old of age. Thirty-three patients with INTRACTABLE EPILEPSY (10-162 months) and 33 patients with controlled epilepsy (14-173 months) wereenrolled. The study was conducted in Pediatric Neurology Clinic of MofidChildren Hospital, Tehran, Iran from January 2010 to December 2010.Patients’ clinical manifestations, laboratory and neuroimaging findings werecollected. Non-fasting plasma 5’- pyridoxal phosphate levels of these subjectswere assessed by high-pressure liquid chromatography.ResultsMean plasma 5’- pyridoxal phosphate level (PLP) in patients with controlledepilepsy was 76.78±37.24 (nmol/l) (15.5-232.4). In patients with intractableepilepsy, mean plasma 5´- pyridoxal phosphate was 98.67 ± 80.58 (25.5-393) nmol/l. There was no statistically significant difference between plasmapyridoxal phosphate levels of these two groups (P═0.430).ConclusionPYRIDOXINE DEPENDENT EPILEPSY is under diagnosed because it is manifestedby various types of seizures. PLASMA PYRIDOXAL PHOSPHATE LEVELs did not differin our patients with intractable or controlled epilepsy. If PDE is suspectedon clinical basis, molecular investigation of ALDH7A1 mutations, as feasibletest, until PDE biomarkers becomes available is recommended.

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    APA: Copy

    PIRZADEH, ZAHRA, GHOFRANI, MOHAMMAD, & MOLLAMOHAMMADI, MOHSEN. (2017). PLASMA PYRIDOXAL 5'-PHOSPHATE LEVEL IN CHILDREN WITH INTRACTABLE AND CONTROLLED EPILEPSY. IRANIAN JOURNAL OF CHILD NEUROLOGY (IJCN), 11(2), 31-36. SID. https://sid.ir/paper/303524/en

    Vancouver: Copy

    PIRZADEH ZAHRA, GHOFRANI MOHAMMAD, MOLLAMOHAMMADI MOHSEN. PLASMA PYRIDOXAL 5'-PHOSPHATE LEVEL IN CHILDREN WITH INTRACTABLE AND CONTROLLED EPILEPSY. IRANIAN JOURNAL OF CHILD NEUROLOGY (IJCN)[Internet]. 2017;11(2):31-36. Available from: https://sid.ir/paper/303524/en

    IEEE: Copy

    ZAHRA PIRZADEH, MOHAMMAD GHOFRANI, and MOHSEN MOLLAMOHAMMADI, “PLASMA PYRIDOXAL 5'-PHOSPHATE LEVEL IN CHILDREN WITH INTRACTABLE AND CONTROLLED EPILEPSY,” IRANIAN JOURNAL OF CHILD NEUROLOGY (IJCN), vol. 11, no. 2, pp. 31–36, 2017, [Online]. Available: https://sid.ir/paper/303524/en

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