INFANTILE SPASMS TREATED WITH INTRAVENOUS METHYPREDINSOLONE PULSE

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HASSANZADEH RAD AFAGH; AMINZADEH VAHID

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Journal Paper

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Journal: Iranian Journal of Child Neurology Year:2017 | Volume:11 | Issue:2 Page(s): 8-12

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Title

INFANTILE SPASMS TREATED WITH INTRAVENOUS METHYPREDINSOLONE PULSE

Author(s)

HASSANZADEH RAD AFAGH | AMINZADEH VAHID | Issue Writer Certificate

Keywords

INFANTILE SPASMS

PREDNISOLONE

ADMINISTRATION

INTRAVENOUS

Abstract

ObjectiveINFANTILE SPASMS is diagnosed late even by expert pediatricians. Late diagnosis(later than 3 weeks) can have a negative effect on the long-term prognosis. Weaimed to investigate INFANTILE SPASMS treated with INTRAVENOUS methylprednisolonepulse.Materials & MethodsIn this case series study, 20 infants with INFANTILE SPASMS in 17-Shahrivar Hospital, Rasht, Iran were enrolled. Drugs were administered based on Mytinger protocolthat included 3 days of methylprednisolone pulse and 56 days of oral PREDNISOLONE.The control of spasms and the omission of hypsarrhythmia in infants followupwere the primary and secondary outcomes, respectively. Remission wasindicated if the caregivers mentioned no spasms or>50% decrease regardingdrug initiation for at least 5 consecutive days and the electroencephalographyduring sleep period noted the omission of hypsarrhythmia.ResultsEleven female (55%) and 9 male (45%) patients with the mean age of 4.95±1.39months were enrolled. Mean rapid remission was noted as 4.41±1.50 days.Twelve patients (60%) noted early remission. seizure was controlled in 3 (15%)patients completely after 24 months. Five (25%) occasional seizures were notedcontrolled by routine anticonvulsant drugs after 24 months and 12 (60%) noresponse was mentioned. Most of the patients (65%) had cryptogenic etiologyfor INFANTILE SPASMS. Uncontrolled seizure was mentioned after initial remission.ConclusionMethyl PREDNISOLONE is an appropriate drug based on easy administering, lowcost, and its accessibility.

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APA: Copy

HASSANZADEH RAD, AFAGH, & AMINZADEH, VAHID. (2017). INFANTILE SPASMS TREATED WITH INTRAVENOUS METHYPREDINSOLONE PULSE. IRANIAN JOURNAL OF CHILD NEUROLOGY (IJCN), 11(2), 8-12. SID. https://sid.ir/paper/303533/en

Vancouver: Copy

HASSANZADEH RAD AFAGH, AMINZADEH VAHID. INFANTILE SPASMS TREATED WITH INTRAVENOUS METHYPREDINSOLONE PULSE. IRANIAN JOURNAL OF CHILD NEUROLOGY (IJCN)[Internet]. 2017;11(2):8-12. Available from: https://sid.ir/paper/303533/en

IEEE: Copy

AFAGH HASSANZADEH RAD, and VAHID AMINZADEH, “INFANTILE SPASMS TREATED WITH INTRAVENOUS METHYPREDINSOLONE PULSE,” IRANIAN JOURNAL OF CHILD NEUROLOGY (IJCN), vol. 11, no. 2, pp. 8–12, 2017, [Online]. Available: https://sid.ir/paper/303533/en

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