HLA-B*1502 IN IRANIAN CHILDREN WITH ANTICONVULSANT DRUGS-INDUCED SKIN REACTIONS

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TONEKABONI SEYED HASAN; JAFARI NARJES; MANSOURI MAHBOUBEH; JABBEHDARI SAYENA; EFTEKHARI RAHIL; CHAVOSHZADEH ZAHRA; ABDOLLAH GORJI FATEMEH; MESDAGHI MEHRNAZ

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Journal Paper

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Journal: Iranian Journal of Child Neurology Year:2017 | Volume:11 | Issue:2 Page(s): 26-30

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Title

HLA-B*1502 IN IRANIAN CHILDREN WITH ANTICONVULSANT DRUGS-INDUCED SKIN REACTIONS

Author(s)

Keywords

DRUG ERUPTION

HLA- B*1502

ANTICONVULSANTS

Abstract

ObjectiveAnticonvulsant drugs can cause various forms of skin drug reactions, rangingfrom exanthema to severe blistering reactions. An association betweenHLA-B*1502 allele and severe skin reactions have been reported.Materials & MethodsFifteen patients with severe skin reactions following treatment withanticonvulsant drugs (Carbamazepine, lamotrigine, phenobarbital, primidone)and 15 controls (age-matched epileptic patients taking similar ANTICONVULSANTSwithout DRUG ERUPTION) were included. They were referred to Mofid Children’sHospital in Tehran, Iran, between Jan 2012 to Jan 2014. Genomic DNA wasextracted from peripheral blood of all patients and HLA- B*1502 genotype wasdetected by real-time PCR.ResultsNone of the patients was positive for HLA- B*1502, but two patients in controlgroup had positive HLA- B*1502.ConclusionThe HLA- B*1502 is not correlated with severe anticonvulsant drugs -inducedskin reactions in Iranian children.

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APA: Copy

TONEKABONI, SEYED HASAN, JAFARI, NARJES, MANSOURI, MAHBOUBEH, JABBEHDARI, SAYENA, EFTEKHARI, RAHIL, CHAVOSHZADEH, ZAHRA, ABDOLLAH GORJI, FATEMEH, & MESDAGHI, MEHRNAZ. (2017). HLA-B*1502 IN IRANIAN CHILDREN WITH ANTICONVULSANT DRUGS-INDUCED SKIN REACTIONS. IRANIAN JOURNAL OF CHILD NEUROLOGY (IJCN), 11(2), 26-30. SID. https://sid.ir/paper/303535/en

Vancouver: Copy

TONEKABONI SEYED HASAN, JAFARI NARJES, MANSOURI MAHBOUBEH, JABBEHDARI SAYENA, EFTEKHARI RAHIL, CHAVOSHZADEH ZAHRA, ABDOLLAH GORJI FATEMEH, MESDAGHI MEHRNAZ. HLA-B*1502 IN IRANIAN CHILDREN WITH ANTICONVULSANT DRUGS-INDUCED SKIN REACTIONS. IRANIAN JOURNAL OF CHILD NEUROLOGY (IJCN)[Internet]. 2017;11(2):26-30. Available from: https://sid.ir/paper/303535/en

IEEE: Copy

SEYED HASAN TONEKABONI, NARJES JAFARI, MAHBOUBEH MANSOURI, SAYENA JABBEHDARI, RAHIL EFTEKHARI, ZAHRA CHAVOSHZADEH, FATEMEH ABDOLLAH GORJI, and MEHRNAZ MESDAGHI, “HLA-B*1502 IN IRANIAN CHILDREN WITH ANTICONVULSANT DRUGS-INDUCED SKIN REACTIONS,” IRANIAN JOURNAL OF CHILD NEUROLOGY (IJCN), vol. 11, no. 2, pp. 26–30, 2017, [Online]. Available: https://sid.ir/paper/303535/en

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