PLASMA AMMONIA LEVELS IN NEWBORNS WITH ASPHYXIA

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KHALESSI NASRIN; KHOSRAVI NASTARAN; MIRJAFARI Maryam; AFSHARKHAS LADAN

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Journal Paper

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Journal: Iranian Journal of Child Neurology Year:2016 | Volume:10 | Issue:1 Page(s): 0-0

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Title

PLASMA AMMONIA LEVELS IN NEWBORNS WITH ASPHYXIA

Author(s)

KHALESSI NASRIN | KHOSRAVI NASTARAN | MIRJAFARI Maryam | AFSHARKHAS LADAN | Issue Writer Certificate

Keywords

ASPHYXIA

HYPERAMMONEMIA

NEONATES

Abstract

Objective Perinatal ASPHYXIA may result in hypoxic damage in various body organs, especially in the central nervous system. It could induce cascade of biochemical events leading to the cell death and metabolic changes, eventually may increase plasma ammonia levels. The purpose of this study was to determine the prevalence of HYPERAMMONEMIA in NEONATES with ASPHYXIA and to find the relationship between ammonia levels and severity of ASPHYXIA.Material & Methods In this cross-sectional study, we included 100 NEONATES with perinatal ASPHYXIA in the Neonatal Intensive Care Unit of Ali-Asghar Hospital, Iran University of Medical Science, Tehran, Iran in 2010-2011. All full term patients diagnosed of ASPHYXIA were enrolled. The relationship between plasma ammonia levels and sex, gestational age, birth weight and severity of ASPHYXIA were determined.Data were analyzed using SPSS software.Results Fifty six percent of NEONATES were male. The mean gestational age was 38.0 ± 1.2 wk. Mean plasma ammonia level was 222 ± 100 mg/dl and 20% of the NEONATES had HYPERAMMONEMIA. It was not associated with gender, gestational age, birth weight, and ASPHYXIA severity. Six patients died and mean plasma ammonia levels was 206±122 mg/dl. In this group, there was no significant relation between plasma ammonia levels and severity of ASPHYXIA. No significant different was seen between plasma ammonia in dead and lived NEONATES.Conclusion According to high prevalence of HYPERAMMONEMIA in neonatal ASPHYXIA, measurement of plasma ammonia levels, is suggested to improve management of ASPHYXIA.

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APA: Copy

KHALESSI, NASRIN, KHOSRAVI, NASTARAN, MIRJAFARI, Maryam, & AFSHARKHAS, LADAN. (2016). PLASMA AMMONIA LEVELS IN NEWBORNS WITH ASPHYXIA. IRANIAN JOURNAL OF CHILD NEUROLOGY (IJCN), 10(1), 0-0. SID. https://sid.ir/paper/303557/en

Vancouver: Copy

KHALESSI NASRIN, KHOSRAVI NASTARAN, MIRJAFARI Maryam, AFSHARKHAS LADAN. PLASMA AMMONIA LEVELS IN NEWBORNS WITH ASPHYXIA. IRANIAN JOURNAL OF CHILD NEUROLOGY (IJCN)[Internet]. 2016;10(1):0-0. Available from: https://sid.ir/paper/303557/en

IEEE: Copy

NASRIN KHALESSI, NASTARAN KHOSRAVI, Maryam MIRJAFARI, and LADAN AFSHARKHAS, “PLASMA AMMONIA LEVELS IN NEWBORNS WITH ASPHYXIA,” IRANIAN JOURNAL OF CHILD NEUROLOGY (IJCN), vol. 10, no. 1, pp. 0–0, 2016, [Online]. Available: https://sid.ir/paper/303557/en

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