ZN/CU LEVELS IN THE FIELD OF AUTISM DISORDERS: A SYSTEMATIC REVIEW AND META-ANALYSIS

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SAYEHMIRI FATEMEH; BABAKNEJAD NASIM; BAHRAMI SOMAYEH; SAYEHMIRI KOUROSH; DARABI MOJTABA; REZAEI TAVIRANI MOSTAFA

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Journal Paper

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Journal: Iranian Journal of Child Neurology Year:2015 | Volume:9 | Issue:4 Page(s): 1-9

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Title

ZN/CU LEVELS IN THE FIELD OF AUTISM DISORDERS: A SYSTEMATIC REVIEW AND META-ANALYSIS

Author(s)

Keywords

ZINC

CUPPER

CONCENTRATION

AUTISM SPECTRUM DISORDERS

METAANALYSIS

Abstract

Objective There is probably a relationship between ZINC/cupper CONCENTRATION in individuals with autism. The present review was written to estimate this probability by using meta-analysis method.Martials & Methods In this meta-analysis of Fixed Effect Model, by searching PubMed, Scopus and Google scholar databases, 11 articles were selected and verified published in 1978 to 2012. I² statistics were calculated to examine heterogeneity. The information was analyzed by R and STATA Ver.11.2.Results Due to non-uniform measurement methods of Zn/Cu CONCENTRATIONs, the CONCENTRATION of these elements was measured in various subgroups (plasma, hair and general) in both study cases and controls. There was a significant statistical difference between plasma OR=0.252 (95% CI: -0.001-0.504) and hair OR=0.27 (95% CI: 0.059-0.481, P=0.01) CONCENTRATIONs of Zn/Cu statuses between controls and autistic patients. Using a Fixed Effects Model, the overall integration of data from the two groups was significant as risk factor OR=0.31 (95% CI: 0.16-0.46, P=0.001).Conclusion Significant correlation existed between Zn/Cu levels and the development of autistic disorders in general analysis. Therefore, Zn/Cu levels could be mentioned as a pathogenesis reason of AUTISM SPECTRUM DISORDERS.

Cites

THE EFFECTS OF ENVIRONMENTAL FACTORS AND IMMUNE DEFICIENCY IN THE ETIOLOGY OF AUTISTIC BEHAVIOR

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APA: Copy

SAYEHMIRI, FATEMEH, BABAKNEJAD, NASIM, BAHRAMI, SOMAYEH, SAYEHMIRI, KOUROSH, DARABI, MOJTABA, & REZAEI TAVIRANI, MOSTAFA. (2015). ZN/CU LEVELS IN THE FIELD OF AUTISM DISORDERS: A SYSTEMATIC REVIEW AND META-ANALYSIS. IRANIAN JOURNAL OF CHILD NEUROLOGY (IJCN), 9(4), 1-9. SID. https://sid.ir/paper/303592/en

Vancouver: Copy

SAYEHMIRI FATEMEH, BABAKNEJAD NASIM, BAHRAMI SOMAYEH, SAYEHMIRI KOUROSH, DARABI MOJTABA, REZAEI TAVIRANI MOSTAFA. ZN/CU LEVELS IN THE FIELD OF AUTISM DISORDERS: A SYSTEMATIC REVIEW AND META-ANALYSIS. IRANIAN JOURNAL OF CHILD NEUROLOGY (IJCN)[Internet]. 2015;9(4):1-9. Available from: https://sid.ir/paper/303592/en

IEEE: Copy

FATEMEH SAYEHMIRI, NASIM BABAKNEJAD, SOMAYEH BAHRAMI, KOUROSH SAYEHMIRI, MOJTABA DARABI, and MOSTAFA REZAEI TAVIRANI, “ZN/CU LEVELS IN THE FIELD OF AUTISM DISORDERS: A SYSTEMATIC REVIEW AND META-ANALYSIS,” IRANIAN JOURNAL OF CHILD NEUROLOGY (IJCN), vol. 9, no. 4, pp. 1–9, 2015, [Online]. Available: https://sid.ir/paper/303592/en

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