IMMUNOLOGICAL EFFECTS OF LEISHMANIA MAJOR SECRETORY AND EXCRETORY PRODUCTS ON CUTANEOUS LEISHMANIASIS IN BALB/C MICE

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MEHRANI H.; MAHMOUDZADEH POURNAKI ABAS

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

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Journal: Iranian Journal of Parasitology Year:2007 | Volume:2 | Issue:2 Page(s): 9-19

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Title

IMMUNOLOGICAL EFFECTS OF LEISHMANIA MAJOR SECRETORY AND EXCRETORY PRODUCTS ON CUTANEOUS LEISHMANIASIS IN BALB/C MICE

Author(s)

MEHRANI H. | MAHMOUDZADEH POURNAKI ABAS | Issue Writer Certificate

Keywords

LEISHMANIA MAJOR

EXCRETORY-SECRETORY PROTEINS

CYTOKINES

BALB/C ACETYLCHOLINESTERASE

Abstract

Background: To evaluate the immunological properties of LEISHMANIA MAJOR excreted- secreted (E-S) products on the progress of leishmaniasis in susceptible BALB/c mice.Methods: Promastigotes of the LEISHMANIA MAJOR were cultured and E-S products were collected during the culture preiod. Groups of BALB/c mice (n=12) were immunized with E-S products or whole antigen. Animals were challenged with promastigotes of stationary phase culture, then mortality was followed up to 6 months. In another group of animals drainage lymph nods cells were removed and cultured for CYTOKINES assay.Results: Activity of acteylcholinesters (AChE) and acid phosphatase (ACP) incresed time dependently. Using SDS-PAGE two major protein bands of 110 and 75 kDa were seen on the gel. Wound diameter in group receiving 24 h E-S products was significantly lower than the other experimental groups (P< 0.05). During the first 4 months of the follow up no mortality was seen in this group, but mortality was started in the second months of the challenge in other groups. The IL-4 and IL-10 level in whole Ag group were significantly higher than the other groups. In cells from animals receiving 24 h E-S products the IL-2 level was significantly higher than the other experimental groups (P< 0.05). Also the IFN g level was significantly higher both in 24 h E-S and whole Ag groups (P< 0.01).Conclusion: The 24 h E-S group corresponded with small wounds, dominant Th1 CYTOKINES response and low level of mortality.

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APA: Copy

MEHRANI, H., & MAHMOUDZADEH POURNAKI, ABAS. (2007). IMMUNOLOGICAL EFFECTS OF LEISHMANIA MAJOR SECRETORY AND EXCRETORY PRODUCTS ON CUTANEOUS LEISHMANIASIS IN BALB/C MICE. IRANIAN JOURNAL OF PARASITOLOGY, 2(2), 9-19. SID. https://sid.ir/paper/303816/en

Vancouver: Copy

MEHRANI H., MAHMOUDZADEH POURNAKI ABAS. IMMUNOLOGICAL EFFECTS OF LEISHMANIA MAJOR SECRETORY AND EXCRETORY PRODUCTS ON CUTANEOUS LEISHMANIASIS IN BALB/C MICE. IRANIAN JOURNAL OF PARASITOLOGY[Internet]. 2007;2(2):9-19. Available from: https://sid.ir/paper/303816/en

IEEE: Copy

H. MEHRANI, and ABAS MAHMOUDZADEH POURNAKI, “IMMUNOLOGICAL EFFECTS OF LEISHMANIA MAJOR SECRETORY AND EXCRETORY PRODUCTS ON CUTANEOUS LEISHMANIASIS IN BALB/C MICE,” IRANIAN JOURNAL OF PARASITOLOGY, vol. 2, no. 2, pp. 9–19, 2007, [Online]. Available: https://sid.ir/paper/303816/en

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