DOSE-DEPENDENT EFFECT OF THYMOQUINONE ON MARKERS OF OXIDATIVE STRESS IN RENAL TISSUE OF DIABETIC RATS

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

ROGHANI MEHRDAD; BALUCHNEJADMOJARAD TOURANDOKHT

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Daneshvar Medicine: Basic and Clinical Research Journal Year:2012 | Volume:19 | Issue:96 Page(s): 57-64

Download Full-Text

Persian Verion

View:

841

Download:

Cites:

Information Journal Paper

Title

DOSE-DEPENDENT EFFECT OF THYMOQUINONE ON MARKERS OF OXIDATIVE STRESS IN RENAL TISSUE OF DIABETIC RATS

Author(s)

ROGHANI MEHRDAD | BALUCHNEJADMOJARAD TOURANDOKHT | Issue Writer Certificate

Keywords

THYMOQUINONEQ3

DIABETES MELLITUSQ3

MALONDIALDEHYDEQ2

SUPEROXIDE DISMUTASEQ2

NITRIC OXIDE METABOLITEQ2

KIDNEYQ2

Abstract

Background and Objective: Due to important role of enhanced oxidative stress in development of renal disorder in diabetes and with regard to antidiabetic and antioxidant effect of THYMOQUINONE, this study was conducted to evaluate the effect of its administration on renal tissue level of some markers of oxidative stress in diabetic rats.Materials and Methods: In this experimental study, Wistar rats were divided into 5 groups, i.e. control, high dose THYMOQUINONE-treated control (20 mg/kg), diabetic, and THYMOQUINONE-treated diabetic groups (10 and 20 mg/kg). After 4 weeks, tissue level of MALONDIALDEHYDE and nitrite and activity of SUPEROXIDE DISMUTASE (SOD) in KIDNEY tissue were measured.Results: Diabetic rats showed a significant increase in tissue level of MALONDIALDEHYDE (p<0.01) and nitrite (p<0.05) and a significant reduction in SOD activity (p<0.05) and THYMOQUINONE treatment at a high dose significantly reduced only levels of MDA and nitrite (p<0.05) and SOD activity in treated-diabetic groups was non-significantly higher as compared to diabetics.Conclusion: Chronic treatment with THYMOQUINONE dose-dependently could attenuate some markers of oxidative stress in renal tissue from diabetic rats.

Cites

No record.

References

No record.

Cite

APA: Copy

ROGHANI, MEHRDAD, & BALUCHNEJADMOJARAD, TOURANDOKHT. (2012). DOSE-DEPENDENT EFFECT OF THYMOQUINONE ON MARKERS OF OXIDATIVE STRESS IN RENAL TISSUE OF DIABETIC RATS. DANESHVAR MEDICINE, 19(96), 57-64. SID. https://sid.ir/paper/30384/en

Vancouver: Copy

ROGHANI MEHRDAD, BALUCHNEJADMOJARAD TOURANDOKHT. DOSE-DEPENDENT EFFECT OF THYMOQUINONE ON MARKERS OF OXIDATIVE STRESS IN RENAL TISSUE OF DIABETIC RATS. DANESHVAR MEDICINE[Internet]. 2012;19(96):57-64. Available from: https://sid.ir/paper/30384/en

IEEE: Copy

MEHRDAD ROGHANI, and TOURANDOKHT BALUCHNEJADMOJARAD, “DOSE-DEPENDENT EFFECT OF THYMOQUINONE ON MARKERS OF OXIDATIVE STRESS IN RENAL TISSUE OF DIABETIC RATS,” DANESHVAR MEDICINE, vol. 19, no. 96, pp. 57–64, 2012, [Online]. Available: https://sid.ir/paper/30384/en

Related Journal Papers