EFFECT OF CHRONIC ADMINISTRATION OF SILYMARIN ON OXIDATIVE STRESS MARKERS IN RENAL TISSUE OF DIABETIC RATS

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ROGHANI M.; BALUCHNEJADMOJARAD T.; ROGHANI DEHKORDI F.

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Journal: Journal of Gorgan University of Medical Sciences Year:2012 | Volume:14 | Issue:2 (42) Page(s): 10-16

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Title

EFFECT OF CHRONIC ADMINISTRATION OF SILYMARIN ON OXIDATIVE STRESS MARKERS IN RENAL TISSUE OF DIABETIC RATS

Author(s)

ROGHANI M. | BALUCHNEJADMOJARAD T. | ROGHANI DEHKORDI F. | Issue Writer Certificate

Keywords

SILYMARINQ2

DIABETES MELLITUSQ3

KIDNEYQ2

OXIDATIVE STRESSQ2

MALONDIALDEHYDEQ2

SUPEROXIDE DISMUTASEQ2

Abstract

Background and Objective: Chronic DIABETES MELLITUS is accompanied with enhanced OXIDATIVE STRESS and reduce the activity of antioxidant defense system. Due to significant role of enhanced OXIDATIVE STRESS in development of renal damage in diabetices, this study was conducted to evaluate the effect of chronic administration of SILYMARIN on OXIDATIVE STRESS markers in renal tissue of diabetic rats.Materials and Methods: In this experimental study, 40 male Wistar rats were divided into 5 groups: control, SILYMARIN-treated control (100 mg/kg bw), diabetic, and SILYMARIN -treated diabetic groups (50 and 100 mg/kg bw). SILYMARIN was administered (daily and intraperitonealy) ten days after Streptozotocin injection for 4 weeks. Tissue level of MALONDIALDEHYDE and nitrite and nitrate and activity of SUPEROXIDE DISMUTASE in KIDNEY tissue were measured. Data were analyzed using ANOVA and Tukey tests.Results: A significant increase in tissue level of MALONDIALDEHYDE, nitrite and nitrate in diabetic rats were observed (P<0.05). SILYMARIN treatment (100 mg/kg/bw) significantly reduced the tissue level of MALONDIALDEHYDE, nitrate and nitrate (P<0.05). Non-significant reduction of activity of SUPEROXIDE DISMUTASE was observed in diabetic rats and SILYMARIN treatment (50 and 100 mg/kg bw) did not significantly altered enzyme activity.Conclusion: Four weeks treatment of SILYMARIN (100 mg/kg bw) reduce OXIDATIVE STRESS indexes in renal tissue of diabetic rats.

Cites

EFFECT OF SALVIA OFFICINALIS L. ON SERUM LEVEL OF GLUCOSE, LIPID PROFILES AND TISSUE LEVEL OF MALONDIALDEHYDE IN DIABETIC RATS

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APA: Copy

ROGHANI, M., BALUCHNEJADMOJARAD, T., & ROGHANI DEHKORDI, F.. (2012). EFFECT OF CHRONIC ADMINISTRATION OF SILYMARIN ON OXIDATIVE STRESS MARKERS IN RENAL TISSUE OF DIABETIC RATS. JOURNAL OF GORGAN UNIVERSITY OF MEDICAL SCIENCES, 14(2 (42)), 10-16. SID. https://sid.ir/paper/79453/en

Vancouver: Copy

ROGHANI M., BALUCHNEJADMOJARAD T., ROGHANI DEHKORDI F.. EFFECT OF CHRONIC ADMINISTRATION OF SILYMARIN ON OXIDATIVE STRESS MARKERS IN RENAL TISSUE OF DIABETIC RATS. JOURNAL OF GORGAN UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2012;14(2 (42)):10-16. Available from: https://sid.ir/paper/79453/en

IEEE: Copy

M. ROGHANI, T. BALUCHNEJADMOJARAD, and F. ROGHANI DEHKORDI, “EFFECT OF CHRONIC ADMINISTRATION OF SILYMARIN ON OXIDATIVE STRESS MARKERS IN RENAL TISSUE OF DIABETIC RATS,” JOURNAL OF GORGAN UNIVERSITY OF MEDICAL SCIENCES, vol. 14, no. 2 (42), pp. 10–16, 2012, [Online]. Available: https://sid.ir/paper/79453/en

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