ANXIOLYTIC AND ANTIDEPRESSANT EFFECTS OF SUMMER SAVORY (SATUREJA HORTENSIS) HYDROALCOHOLIC EXTRACT IN MALE RATS EXPOSED TO CHRONIC RESTRAINT STRESS

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MOGHADDAM FATEMEH; Asle Rousta Masoumeh

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Journal: Daneshvar Medicine: Basic and Clinical Research Journal Year:2016 | Volume:24 | Issue:125 Page(s): 31-38

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Title

ANXIOLYTIC AND ANTIDEPRESSANT EFFECTS OF SUMMER SAVORY (SATUREJA HORTENSIS) HYDROALCOHOLIC EXTRACT IN MALE RATS EXPOSED TO CHRONIC RESTRAINT STRESS

Author(s)

MOGHADDAM FATEMEH | Asle Rousta Masoumeh | Issue Writer Certificate

Keywords

SATUREJA HORTENSIS

ANXIETY

DEPRESSION

RESTRAINT STRESS

Abstract

Background and Objective: Summer savory (SATUREJA HORTENSIS) has antioxidant, anti-inflammatory and analgesic properties. This study was designed to evaluate the effect of SATUREJA HORTENSIS hydro-alcoholic extract on ANXIETY and DEPRESSION in male Wistar rats exposed to chronic immobilization.Materials and Methods: In this experimental study, 48 male Wistar rats were randomly allocated to 6 groups (n=8 for each): control, stress group (6 hours/day during 21 consecutive days RESTRAINT STRESS), Satureja 200 and Satureja 400 (receiving doses 200, 400 mg/kg/bw of hydroalcoholic extract of SATUREJA HORTENSIS), stress-Satureja 200 and stress-Satureja 400 groups (received Satureja extract in addition to chronic immobility stress). At the end of study, ANXIETY and DEPRESSION were evaluated using elevated plus maze and forced swimming test, respectively.Results: The percentages of open arm entry and time spent in open arm significantly increased in satureja-stress groups as compared with stress animals (p<0.01). The results of forced swimming test showed that the immobility time in satureja-stress400 group significantly decreased as compared with stress animals (p<0.05).Conclusion: The results suggested that hydroalcoholic extract of SATUREJA HORTENSIS has anxiolytic effect and at dosage of 400 mg/kg decreases DEPRESSION-like behavior in rats.

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APA: Copy

MOGHADDAM, FATEMEH, & Asle Rousta, Masoumeh. (2016). ANXIOLYTIC AND ANTIDEPRESSANT EFFECTS OF SUMMER SAVORY (SATUREJA HORTENSIS) HYDROALCOHOLIC EXTRACT IN MALE RATS EXPOSED TO CHRONIC RESTRAINT STRESS. DANESHVAR MEDICINE, 24(125 ), 31-38. SID. https://sid.ir/paper/30395/en

Vancouver: Copy

MOGHADDAM FATEMEH, Asle Rousta Masoumeh. ANXIOLYTIC AND ANTIDEPRESSANT EFFECTS OF SUMMER SAVORY (SATUREJA HORTENSIS) HYDROALCOHOLIC EXTRACT IN MALE RATS EXPOSED TO CHRONIC RESTRAINT STRESS. DANESHVAR MEDICINE[Internet]. 2016;24(125 ):31-38. Available from: https://sid.ir/paper/30395/en

IEEE: Copy

FATEMEH MOGHADDAM, and Masoumeh Asle Rousta, “ANXIOLYTIC AND ANTIDEPRESSANT EFFECTS OF SUMMER SAVORY (SATUREJA HORTENSIS) HYDROALCOHOLIC EXTRACT IN MALE RATS EXPOSED TO CHRONIC RESTRAINT STRESS,” DANESHVAR MEDICINE, vol. 24, no. 125 , pp. 31–38, 2016, [Online]. Available: https://sid.ir/paper/30395/en

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