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Information Journal Paper

Title

IL-23 AND IL-27 LEVELS IN MACROPHAGES COLLECTED FROM PERIPHERAL BLOOD OF PATIENTS WITH HEALING VS NON-HEALING FORM OF CUTANEOUS LEISHMANIASIS

Pages

  18-25

Abstract

 Background: In this study the level of IL-23 and IL-27 produced by MACROPHAGES derived from peripheral blood mononuclear cell culture collected from patients with healing or non-healing form of CUTANEOUS LEISHMANIASIS lesion were compared before and after treatment with live Leishmania to explore whether IL-23 or IL-27 plays any role in healing process of cutaneous lesions induced by L. major.Methods: Twenty patients resident in Isfahan Province, with healing or non-healing form of CUTANEOUS LEISHMANIASIS lesion caused by Leishmania major participated in this study. In vitro productions of IL-23 and IL-27 by peripheral blood derived MACROPHAGES, before and after stimulation with liveL. major (MRHO/IR/75/ER) PROMASTIGOTEs were evaluated using ELISA method. Patient with healing form of lesion received no treatment and patient with non-healing form of lesion received at least 2 courses of glucantime.Results: The mean production of IL-23 and IL-27 from MACROPHAGES of patients with healing form of lesion was significantly higher than patients with non-healing form of lesion. The levels of IL-23 and IL-27 in culture supernatants before and after stimulation in healing form of CL was significantly higher than non- healing form of CL (P<0.001).Conclusion: IL-23 and IL-27 might play a role in human leishmaniasis and further studies are needed to understand the role of IL-23 and IL-27 in leishmaniasis.

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    APA: Copy

    TOLOUEI, S., GHAEDI, K., KHAMESIPOUR, A., AKBARI, M., BAGHAEI, M., HASHEMINIA, S.J., NARIMANI, M., & HEJAZI, SH.. (2012). IL-23 AND IL-27 LEVELS IN MACROPHAGES COLLECTED FROM PERIPHERAL BLOOD OF PATIENTS WITH HEALING VS NON-HEALING FORM OF CUTANEOUS LEISHMANIASIS. IRANIAN JOURNAL OF PARASITOLOGY, 7(1), 18-25. SID. https://sid.ir/paper/303996/en

    Vancouver: Copy

    TOLOUEI S., GHAEDI K., KHAMESIPOUR A., AKBARI M., BAGHAEI M., HASHEMINIA S.J., NARIMANI M., HEJAZI SH.. IL-23 AND IL-27 LEVELS IN MACROPHAGES COLLECTED FROM PERIPHERAL BLOOD OF PATIENTS WITH HEALING VS NON-HEALING FORM OF CUTANEOUS LEISHMANIASIS. IRANIAN JOURNAL OF PARASITOLOGY[Internet]. 2012;7(1):18-25. Available from: https://sid.ir/paper/303996/en

    IEEE: Copy

    S. TOLOUEI, K. GHAEDI, A. KHAMESIPOUR, M. AKBARI, M. BAGHAEI, S.J. HASHEMINIA, M. NARIMANI, and SH. HEJAZI, “IL-23 AND IL-27 LEVELS IN MACROPHAGES COLLECTED FROM PERIPHERAL BLOOD OF PATIENTS WITH HEALING VS NON-HEALING FORM OF CUTANEOUS LEISHMANIASIS,” IRANIAN JOURNAL OF PARASITOLOGY, vol. 7, no. 1, pp. 18–25, 2012, [Online]. Available: https://sid.ir/paper/303996/en

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