THE EFFECTS OF BABESIOSIS ON OXIDATIVE STRESS AND DNA DAMAGE IN ANATOLIAN BLACK GOATS NATURALLY INFECTED WITH BABESIA OVIS

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KUCUKKURT ISMAIL; HAKKI CIGERCI I.; INCE SINAN; KOZAN ESMA; AYTEKIN ISMAIL; ERYAVUZ ABDULLAH; FATIH FIDAN A.

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Journal: Iranian Journal of Parasitology Year:2014 | Volume:9 | Issue:1 Page(s): 90-98

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Title

THE EFFECTS OF BABESIOSIS ON OXIDATIVE STRESS AND DNA DAMAGE IN ANATOLIAN BLACK GOATS NATURALLY INFECTED WITH BABESIA OVIS

Author(s)

Keywords

BABESIA OVIS

OXIDATIVE STRESS

DNA DAMAGE

ANTIOXIDANT ACTIVITY

Abstract

Background: A reactive oxygen and nitrogen intermediate produced during an inflammatory response is the important part of host-defense strategies of organ-isms to kill the parasite. However, it is not well known whether these intermediates cause DNA DAMAGE and OXIDATIVE STRESS in goats infected with BABESIA OVIS. The purpose of this study was to clarify the effects of babesiosis on basal levels of DNA DAMAGE and oxidative status of goats naturally infected with B. ovis.Methods: DNA DAMAGE and antioxidant parameters were determined in B. ovis infected goats. Ten infected Anatolian Black Goats with B. ovis diagnosed via clinical signs and microscopic findings and ten healthy were used in the study.Results: The Babesia infection increased the levels of DNA DAMAGE, malondialdehyde (MDA), protein carbonyl content (PCO) and plasma concentration of nitric oxide metabolites (NOx), and decreased total antioxidant activities (AOA) and reduced glutathione (GSH). A significant positive correlation between DNA DAMAGE, MDA, PCO, and NOx concentrations was found in the infected goats. DNA DAMAGE showed a negative association with AOA and GSH concentrations in the in-fected goats.Conclusion: The Babesia infection increases OXIDATIVE STRESS markers and DNA DAMAGE and decreases AOA in goats. These results suggest that the increases in the production of free radicals due to Babesia infection not only contribute to hostdefense strategies of organisms to kill the parasite but also induce oxidative damage in other cells.

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APA: Copy

KUCUKKURT, ISMAIL, HAKKI CIGERCI, I., INCE, SINAN, KOZAN, ESMA, AYTEKIN, ISMAIL, ERYAVUZ, ABDULLAH, & FATIH FIDAN, A.. (2014). THE EFFECTS OF BABESIOSIS ON OXIDATIVE STRESS AND DNA DAMAGE IN ANATOLIAN BLACK GOATS NATURALLY INFECTED WITH BABESIA OVIS. IRANIAN JOURNAL OF PARASITOLOGY, 9(1), 90-98. SID. https://sid.ir/paper/304032/en

Vancouver: Copy

KUCUKKURT ISMAIL, HAKKI CIGERCI I., INCE SINAN, KOZAN ESMA, AYTEKIN ISMAIL, ERYAVUZ ABDULLAH, FATIH FIDAN A.. THE EFFECTS OF BABESIOSIS ON OXIDATIVE STRESS AND DNA DAMAGE IN ANATOLIAN BLACK GOATS NATURALLY INFECTED WITH BABESIA OVIS. IRANIAN JOURNAL OF PARASITOLOGY[Internet]. 2014;9(1):90-98. Available from: https://sid.ir/paper/304032/en

IEEE: Copy

ISMAIL KUCUKKURT, I. HAKKI CIGERCI, SINAN INCE, ESMA KOZAN, ISMAIL AYTEKIN, ABDULLAH ERYAVUZ, and A. FATIH FIDAN, “THE EFFECTS OF BABESIOSIS ON OXIDATIVE STRESS AND DNA DAMAGE IN ANATOLIAN BLACK GOATS NATURALLY INFECTED WITH BABESIA OVIS,” IRANIAN JOURNAL OF PARASITOLOGY, vol. 9, no. 1, pp. 90–98, 2014, [Online]. Available: https://sid.ir/paper/304032/en

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