IN VITRO STUDY ON CYTOTOXIC EFFECTS OF ZNO NANOPARTICLES ON PROMASTIGOTE AND AMASTIGOTE FORMS OF LEISHMANIA MAJOR (MRHO/IR/75/ER)

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DELAVARI MAHDI; DALIMI ABDOLHOSSEIN; GHAFFARIFAR FATEMEH; SADRAEI JAVID

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Journal Paper

Paper Information

Journal: Iranian Journal of Parasitology Year:2014 | Volume:9 | Issue:1 Page(s): 6-13

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Title

IN VITRO STUDY ON CYTOTOXIC EFFECTS OF ZNO NANOPARTICLES ON PROMASTIGOTE AND AMASTIGOTE FORMS OF LEISHMANIA MAJOR (MRHO/IR/75/ER)

Author(s)

DELAVARI MAHDI | DALIMI ABDOLHOSSEIN | GHAFFARIFAR FATEMEH | SADRAEI JAVID | Issue Writer Certificate

Keywords

LEISHMANIA MAJOR

AMASTIGOTE

PROMASTIGOTE

ZNO NANOPARTICLES

APOPTOSIS

MTT ASSAY

Abstract

Background: Although pentavalent antimony compounds are used as antileishmanial drugs but they are associated with limitations and several adverse complications. Therefore, always effort to find a new and effective treatment is desired. In this study, the effect of ZNO NANOPARTICLES with mean particle size of 20 nanometers (nm) on LEISHMANIA MAJOR PROMASTIGOTEs and AMASTIGOTEs was evaluated.Methods: Viability percentage of PROMASTIGOTEs after adding different concentrations of ZNO NANOPARTICLES (30, 60, 90 and 120 mg/ml) to the parasite culture was evaluated by MTT ASSAY. In the flow cytometry study, Annexin V-FITC APOPTOSIS detection Kit was used to study the induced APOPTOSIS and necrotic effects.Result: IC50 after 24 hours of incubation was 37.8 mg/ml. ZNO NANOPARTICLES exert cytotoxic effects on PROMASTIGOTEs of L. major through the induction of APOPTOSIS. A concentration of 120 mg/ml of ZNO NANOPARTICLES induced 93.76% APOPTOSIS in L. major after 72 hours.Conclusion: ZnO NPs can induce APOPTOSIS in L. major by dose and timedepended manner in vitro condition.

Cites

HISTOPATHOLOGY OF EPIDIDYMIS IN ADULT NMRI MALE MICE TREATED WITH ZINC OXIDE NANOPARTICLES

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APA: Copy

DELAVARI, MAHDI, DALIMI, ABDOLHOSSEIN, GHAFFARIFAR, FATEMEH, & SADRAEI, JAVID. (2014). IN VITRO STUDY ON CYTOTOXIC EFFECTS OF ZNO NANOPARTICLES ON PROMASTIGOTE AND AMASTIGOTE FORMS OF LEISHMANIA MAJOR (MRHO/IR/75/ER). IRANIAN JOURNAL OF PARASITOLOGY, 9(1), 6-13. SID. https://sid.ir/paper/304034/en

Vancouver: Copy

DELAVARI MAHDI, DALIMI ABDOLHOSSEIN, GHAFFARIFAR FATEMEH, SADRAEI JAVID. IN VITRO STUDY ON CYTOTOXIC EFFECTS OF ZNO NANOPARTICLES ON PROMASTIGOTE AND AMASTIGOTE FORMS OF LEISHMANIA MAJOR (MRHO/IR/75/ER). IRANIAN JOURNAL OF PARASITOLOGY[Internet]. 2014;9(1):6-13. Available from: https://sid.ir/paper/304034/en

IEEE: Copy

MAHDI DELAVARI, ABDOLHOSSEIN DALIMI, FATEMEH GHAFFARIFAR, and JAVID SADRAEI, “IN VITRO STUDY ON CYTOTOXIC EFFECTS OF ZNO NANOPARTICLES ON PROMASTIGOTE AND AMASTIGOTE FORMS OF LEISHMANIA MAJOR (MRHO/IR/75/ER),” IRANIAN JOURNAL OF PARASITOLOGY, vol. 9, no. 1, pp. 6–13, 2014, [Online]. Available: https://sid.ir/paper/304034/en

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