مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Information Journal Paper

Title

IN VITRO SUSCEPTIBILITY OF IRANIAN ISOLATES OF TRICHOMONAS VAGINALIS TO METRONIDAZOLE

Pages

  46-51

Abstract

 Background: METRONIDAZOLE, a 5-nitroimidazole derivative, is the main antitrichomonal agent of choice for treatment of trichomoniasis. Since 1962, some cases of treatment failure with METRONIDAZOLE have been reported and recently drug resistance is now on the rise in the world. This study was aimed to determine current susceptibility of IRANian isolates of TRICHOMONAS VAGINALIS to METRONIDAZOLE.Methods: This study was performed on 50 T. vaginalis isolates collected from west and central areas of IRAN. After axenisation of the parasites, susceptibility testing was carried out by using serial twofold dilutions of METRONIDAZOLE (400 to 0.1 mg/ml). The minimum inhibitory concentration (MIC) and the minimum lethal concentration (MLC) of the trichomonads were determined after 48 h incubation at 35.5oC. Drug susceptibility assays of the all isolates were carried out two times in triplicate under aerobic and anaerobic conditions.Results: Ninety-eight percent of the T. vaginalis isolates (49/50) were sensitive to METRONIDAZOLE. METRONIDAZOLE resistance was defined as aerobic MIC³50 mg/ml, detected in one isolate. The means of aerobic MICs and MLCs and that of anaerobic MICs of the parasites were 2.91, 1.95 and 0.28 mg/ml, respectively.Conclusion: This investigation showed IN VITRO low-level tolerance to METRONIDAZOLE in a few T. vaginalis isolates that may be leading to the development of drug resistance.

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    APA: Copy

    MATINI, MOHAMMAD, MAGHSOOD, AMIR HOSSEIN, MOHEBALI, MAHDI, RABIEE, SOGHRA, FALLAH, MOHAMMAD, REZAIE, SASSAN, & REZAEIAN, MOSTAFA. (2016). IN VITRO SUSCEPTIBILITY OF IRANIAN ISOLATES OF TRICHOMONAS VAGINALIS TO METRONIDAZOLE. IRANIAN JOURNAL OF PARASITOLOGY, 11(1), 46-51. SID. https://sid.ir/paper/304081/en

    Vancouver: Copy

    MATINI MOHAMMAD, MAGHSOOD AMIR HOSSEIN, MOHEBALI MAHDI, RABIEE SOGHRA, FALLAH MOHAMMAD, REZAIE SASSAN, REZAEIAN MOSTAFA. IN VITRO SUSCEPTIBILITY OF IRANIAN ISOLATES OF TRICHOMONAS VAGINALIS TO METRONIDAZOLE. IRANIAN JOURNAL OF PARASITOLOGY[Internet]. 2016;11(1):46-51. Available from: https://sid.ir/paper/304081/en

    IEEE: Copy

    MOHAMMAD MATINI, AMIR HOSSEIN MAGHSOOD, MAHDI MOHEBALI, SOGHRA RABIEE, MOHAMMAD FALLAH, SASSAN REZAIE, and MOSTAFA REZAEIAN, “IN VITRO SUSCEPTIBILITY OF IRANIAN ISOLATES OF TRICHOMONAS VAGINALIS TO METRONIDAZOLE,” IRANIAN JOURNAL OF PARASITOLOGY, vol. 11, no. 1, pp. 46–51, 2016, [Online]. Available: https://sid.ir/paper/304081/en

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