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Information Journal Paper

Title

Trypanocidal Effects of Cisplatin alone and in Combination with Nigella sativa Oil on Experimentally Infected Mice with Trypanosoma evansi

Pages

  89-99

Abstract

 Background: Due to the limited number of the available drugs for the treatment of trypanosomiasis, this study was designed to evaluate the Trypanocidal effects of Cisplatin or/and Nigella sativa oil (NSO) in experimentally infected Mice with T. evansi. Methods: During 2015 at the Parasitology Department, Menoufia University, Menoufia, Egypt, sixty Swiss albino Mice were divided into six groups: normal control (I), infected control (II); Cisplatin-treated (III); NSO-treated (IV); combined Cisplatin + NSO-treated (V) and Diminazene-treated (VI). The tested drugs were evaluated by the assessment of parasitaemia, measurement of aspartate aminotransferase (AST), alanine aminotransferase (ALT), urea, creatinine, serum IgM and a histopathological study. Results: NSO showed a Trypanocidal effect, however; it was not as effective as Cisplatin or Diminazene. There were significant increases of AST, ALT, urea, and creatinine in group II and III, which were significantly reduced in Cisplatin + NSO-treated group (V). Moreover, there were significant reductions in serum IgM and the pathological changes of the examined organs of group V when they were compared with other treated groups. Conclusion: Cisplatin combined with NSO showed a Trypanocidal effect against T. evansi with preservation of vital organs functions and architecture.

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    APA: Copy

    NASSEF, Nashaat Abd El Monem, EL MELEGY, Manal Ahmed, BESHAY, Engy Victor, Al SHARAKY, Dalia Rifaat, & AL ATTAR, Tahany Mohamed. (2018). Trypanocidal Effects of Cisplatin alone and in Combination with Nigella sativa Oil on Experimentally Infected Mice with Trypanosoma evansi. IRANIAN JOURNAL OF PARASITOLOGY, 13(1), 89-99. SID. https://sid.ir/paper/304135/en

    Vancouver: Copy

    NASSEF Nashaat Abd El Monem, EL MELEGY Manal Ahmed, BESHAY Engy Victor, Al SHARAKY Dalia Rifaat, AL ATTAR Tahany Mohamed. Trypanocidal Effects of Cisplatin alone and in Combination with Nigella sativa Oil on Experimentally Infected Mice with Trypanosoma evansi. IRANIAN JOURNAL OF PARASITOLOGY[Internet]. 2018;13(1):89-99. Available from: https://sid.ir/paper/304135/en

    IEEE: Copy

    Nashaat Abd El Monem NASSEF, Manal Ahmed EL MELEGY, Engy Victor BESHAY, Dalia Rifaat Al SHARAKY, and Tahany Mohamed AL ATTAR, “Trypanocidal Effects of Cisplatin alone and in Combination with Nigella sativa Oil on Experimentally Infected Mice with Trypanosoma evansi,” IRANIAN JOURNAL OF PARASITOLOGY, vol. 13, no. 1, pp. 89–99, 2018, [Online]. Available: https://sid.ir/paper/304135/en

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