Increased CD11b and Hypoxia-Inducible Factors-1alpha Expressions in the Lung Tissue and Surfactant Protein-D Levels in Serum Are Related with Acute Lung Injury in Severe Malaria of C57BL/6 Mice

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CAHAYANI Wike Astrid; NORAHMAWATI Eviana; BUDIARTI Niniek; FITRI Loeki Enggar

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Journal: IRANIAN JOURNAL OF PARASITOLOGY Year:2016 | Volume:11 | Issue:3 Page(s): 303-315

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Title

Increased CD11b and Hypoxia-Inducible Factors-1alpha Expressions in the Lung Tissue and Surfactant Protein-D Levels in Serum Are Related with Acute Lung Injury in Severe Malaria of C57BL/6 Mice

Author(s)

CAHAYANI Wike Astrid | NORAHMAWATI Eviana | BUDIARTI Niniek | FITRI Loeki Enggar | Issue Writer Certificate

Keywords

Acute lung injury

Severe malaria

CD11b

HIF-1alpha

SP-D

Abstract

Background: We aimed to reveal the role of CD11b and hypoxia-inducible factors-1alpha (HIF-1α ) expressions on monocytes and alveolar macrophages of lung tissue, and the levels of serum surfactant protein-D (SP-D) in Severe malaria-associated Acute lung injury (ALI). Methods: The C57BL/6 mice were divided into control group, renal malaria group (inoculated with 106 Plasmodium berghei ANKA), and cerebral malaria group (inoculated with 107 P. berghei ANKA). The expressions of CD11b and HIF-1α in lung tissue were observed by immunohistochemistry, and serum SP-D levels were measured by ELISA. This study was conducted from June 2014 to February 2015 in the Laboratory of Parasitology, Faculty of Medicine, Universitas Brawijaya, Malang. Results: The CD11b expression on pulmonary tissue of renal and cerebral malaria mice were significantly higher than control mice (P=0. 002; P=0. 002), as well as the HIF-1α expression on pulmonary tissue (P=0. 002; P=0. 002). The level of serum SP-D in renal malaria and cerebral malaria mice were significantly higher than control mice (P=0. 002; P=0. 002). We found a strong correlation between the expression of CD11b and HIF-1α in lung tissue (r=0. 937, P=0. 000), as well as between CD11b expression and serum SP-D levels (r=0. 907, P=0. 000) and between HIF-1α expression and serum SP-D levels (r=0. 913, P=0. 000). Conclusion: Severe malaria-associated ALI increased the expression of CD11b and HIF-1α in the lung tissue and increased serum SP-D levels of C57BL/6 mice significantly.

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APA: Copy

CAHAYANI, Wike Astrid, NORAHMAWATI, Eviana, BUDIARTI, Niniek, & FITRI, Loeki Enggar. (2016). Increased CD11b and Hypoxia-Inducible Factors-1alpha Expressions in the Lung Tissue and Surfactant Protein-D Levels in Serum Are Related with Acute Lung Injury in Severe Malaria of C57BL/6 Mice. IRANIAN JOURNAL OF PARASITOLOGY, 11(3), 303-315. SID. https://sid.ir/paper/304207/en

Vancouver: Copy

CAHAYANI Wike Astrid, NORAHMAWATI Eviana, BUDIARTI Niniek, FITRI Loeki Enggar. Increased CD11b and Hypoxia-Inducible Factors-1alpha Expressions in the Lung Tissue and Surfactant Protein-D Levels in Serum Are Related with Acute Lung Injury in Severe Malaria of C57BL/6 Mice. IRANIAN JOURNAL OF PARASITOLOGY[Internet]. 2016;11(3):303-315. Available from: https://sid.ir/paper/304207/en

IEEE: Copy

Wike Astrid CAHAYANI, Eviana NORAHMAWATI, Niniek BUDIARTI, and Loeki Enggar FITRI, “Increased CD11b and Hypoxia-Inducible Factors-1alpha Expressions in the Lung Tissue and Surfactant Protein-D Levels in Serum Are Related with Acute Lung Injury in Severe Malaria of C57BL/6 Mice,” IRANIAN JOURNAL OF PARASITOLOGY, vol. 11, no. 3, pp. 303–315, 2016, [Online]. Available: https://sid.ir/paper/304207/en

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