THE EFFECT OF HORMONE REPLACEMENT THERAPY AND OXYBUTYNIN IN MENOPAUSAL WOMEN WITH IDIOPATHIC DETRUSOR INSTABILITY

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TAM L.; ZIAEE S.

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Journal: Daneshvar Medicine: Basic and Clinical Research Journal Year:2004 | Volume:11 | Issue:50 Page(s): 51-60

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Title

THE EFFECT OF HORMONE REPLACEMENT THERAPY AND OXYBUTYNIN IN MENOPAUSAL WOMEN WITH IDIOPATHIC DETRUSOR INSTABILITY

Author(s)

TAM L. | ZIAEE S. | Issue Writer Certificate

Keywords

IDIOPATHIC DERUSOR INSTABILITYQ4

MENOPAUSAL WOMENQ2

OXYBUTYNINQ4

HORMONE REPLACEMENT THERAPYQ4

CYSTOMETRYQ4

Abstract

To assess the efficacy of HORMONE REPLACEMENT THERAPY and OXYBUTYNIN in treating MENOPAUSAL WOMEN with idiopathic detrusor instability.41 MENOPAUSAL WOMEN complaining of urge incontinence referred to Imam Khomeini and Baharloo hospitals, and they had inclusion criteria, after routine laboratory investigation were normal, they were evaluated with simple CYSTOMETRY.Derusor instability in performed CYSTOMETRY was proved in 32 patients. The participations were treated randomly by combination of HORMONE REPLACEMENT THERAPY and OXYBUTYNIN or OXYBUTYNIN alone. HORMONE REPLACEMENT THERAPY was prescribed continuously conjugated estrogen (0.625 mg) and medroxyprogestrone (25 mg) daily, and for two treatment groups;starting dosage of OXYBUTYNIN was 2.5 mg twice a day.Patients were followed in interval 3 weeks, if symptoms of illness weren"t improvement, OXYBUTYNINwas increasedto prior diet drug with 5 mg dosage. Ten patients were lost to follow up, therefore22 patients followed for 3 months, ten of them had used OXYBUTYNIN alone and the rest had used OXYBUTYNIN and HORMONE REPLACEMENT THERAPY. Cystometric test was performed after treatment on seven patients in treatment group HORMONE REPLACEMENT THERAPY and OXYBUTYNIN; and ten patients on OXYBUTYNIN therapy.Objective evaluation cystometric included post void residual urine volume, volume of first sensation to void, volume of bladder threshold, maximal cystometric capacity and being detrusor instability which were evaluated by performed CYSTOMETRY prior and after treatment. Symptoms of illness evaluated including frequency of urge incontinence, diurnal and nocturnal voluntary micturition by voiding diary during 72 hours after and prior treatment those patients completed them. Scores of urgency urge incontinence, amount of incontinence, to use pad, patient’s perception of their improvement and side effects of drug were evaluated by questionnaire prior and after treatment.There were no significant differences in cystometric variables between two treatment groups, but there was appositive borderline effect in maximal cystometric capacity after. treatment combination of OXYBUTYNIN and HORMONE REPLACEMENT THERAPY (P=O.056); in addition one of patients who had combination therapy had stable bladder and maximal cystometric capacity was more than 350 mL whereas there wasn’t this group of OXYBUTYNIN therapy. There were no significant differences in symptoms of illness, degree of improvement and anticholinergic side effects between two treatment groups.The preferences of OXYBUTYNIN and HORMONE REPLACEMENT THERAPY in comparison with OXYBUTYNIN alone in treatment idiopathic detrusor instability was not clearly proved, it is necessary to perform more extensivestrldies.

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APA: Copy

TAM, L., & ZIAEE, S.. (2004). THE EFFECT OF HORMONE REPLACEMENT THERAPY AND OXYBUTYNIN IN MENOPAUSAL WOMEN WITH IDIOPATHIC DETRUSOR INSTABILITY. DANESHVAR MEDICINE, 11(50), 51-60. SID. https://sid.ir/paper/30430/en

Vancouver: Copy

TAM L., ZIAEE S.. THE EFFECT OF HORMONE REPLACEMENT THERAPY AND OXYBUTYNIN IN MENOPAUSAL WOMEN WITH IDIOPATHIC DETRUSOR INSTABILITY. DANESHVAR MEDICINE[Internet]. 2004;11(50):51-60. Available from: https://sid.ir/paper/30430/en

IEEE: Copy

L. TAM, and S. ZIAEE, “THE EFFECT OF HORMONE REPLACEMENT THERAPY AND OXYBUTYNIN IN MENOPAUSAL WOMEN WITH IDIOPATHIC DETRUSOR INSTABILITY,” DANESHVAR MEDICINE, vol. 11, no. 50, pp. 51–60, 2004, [Online]. Available: https://sid.ir/paper/30430/en

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