FLEXIBLE, MULTI-DOSE GNRH ANTAGONIST VERSUS LONG GNRH AGONIST PROTOCOL IN POOR RESPONDERS: A RANDOMIZED CONTROLLED TRIAL

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SHAHROKH TEHRANINEZHAD E.; FAZEL AZADEH; SAMIEI ARASH; RASHIDI B.; KIANI KIANDOKHT

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Journal Paper

Paper Information

Journal: International Journal of Fertility & Sterility Year:2009 | Volume:2 | Issue:4 Page(s): 165-168

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Title

FLEXIBLE, MULTI-DOSE GNRH ANTAGONIST VERSUS LONG GNRH AGONIST PROTOCOL IN POOR RESPONDERS: A RANDOMIZED CONTROLLED TRIAL

Author(s)

Keywords

GNRH AGONIST

GNRH ANTAGONIST

IVF

POOR OVARIAN FUNCTION

Abstract

Background: To compare a flexible, multi-dose GNRH ANTAGONIST protocol with a long GNRH AGONIST protocol in poor responders. Materials and Methods: A randomized clinical trial of 70 poor responder patients (35 patients in GNRH ANTAGONIST protocol and 35 patients in long GNRH AGONIST protocol) was performed at Royan Institute, Tehran, Iran. Both groups were given a fixed dose of human menopausal gonadotropin (HMG) for stimulation and oral contraceptive pre-treatment. Data analyzed by student’s group t-test or Chi square test. Results: Stimulation duration, total gonadotrophins consumption, mean numbers of oocytes retrieved, formed embryos, cycle cancellation rate, and clinical pregnancy rate were similar between both groups. Although the miscarriage rate was higher in the agonist protocol group, the rate of miscarriage was not statistically significant between both groups. Conclusion: A flexible, multi-dose GNRH ANTAGONIST protocol appears as effective as the long GNRH AGONIST protocol in poor responders. More (larger) randomized controlled trials for better statistical analysis are recommended.

Cites

MICRODOSE GNRH AGONIST FLARE-UP VERSUS ULTRASHORT GNRH AGONIST COMBINED WITH FIXED GNRH ANTAGONIST IN POOR RESPONDERS OF ASSISTED REPRODUCTIVE TECHNIQUES CYCLES

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APA: Copy

SHAHROKH TEHRANINEZHAD, E., FAZEL, AZADEH, SAMIEI, ARASH, RASHIDI, B., & KIANI, KIANDOKHT. (2009). FLEXIBLE, MULTI-DOSE GNRH ANTAGONIST VERSUS LONG GNRH AGONIST PROTOCOL IN POOR RESPONDERS: A RANDOMIZED CONTROLLED TRIAL. INTERNATIONAL JOURNAL OF FERTILITY AND STERILITY, 2(4), 165-168. SID. https://sid.ir/paper/304460/en

Vancouver: Copy

SHAHROKH TEHRANINEZHAD E., FAZEL AZADEH, SAMIEI ARASH, RASHIDI B., KIANI KIANDOKHT. FLEXIBLE, MULTI-DOSE GNRH ANTAGONIST VERSUS LONG GNRH AGONIST PROTOCOL IN POOR RESPONDERS: A RANDOMIZED CONTROLLED TRIAL. INTERNATIONAL JOURNAL OF FERTILITY AND STERILITY[Internet]. 2009;2(4):165-168. Available from: https://sid.ir/paper/304460/en

IEEE: Copy

E. SHAHROKH TEHRANINEZHAD, AZADEH FAZEL, ARASH SAMIEI, B. RASHIDI, and KIANDOKHT KIANI, “FLEXIBLE, MULTI-DOSE GNRH ANTAGONIST VERSUS LONG GNRH AGONIST PROTOCOL IN POOR RESPONDERS: A RANDOMIZED CONTROLLED TRIAL,” INTERNATIONAL JOURNAL OF FERTILITY AND STERILITY, vol. 2, no. 4, pp. 165–168, 2009, [Online]. Available: https://sid.ir/paper/304460/en

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