مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Information Journal Paper

Title

MICRODOSE GNRH AGONIST FLARE-UP VERSUS ULTRASHORT GNRH AGONIST COMBINED WITH FIXED GNRH ANTAGONIST IN POOR RESPONDERS OF ASSISTED REPRODUCTIVE TECHNIQUES CYCLES

Pages

  266-271

Abstract

 Background: This study compares the microdose flare-up protocol to the ultrashort gonadotropin releasing hormone (GnRH) agonist flare combined with the fixed multidose GNRH ANTAGONIST protocol in POOR RESPONDERs undergoing ovarian stimulation.Materials and Methods: In this randomized clinical trial, 120 women who were candidates for assisted reproductive techniques (ART) and had histories of one or more failedin vitro fertilization (IVF) cycles with three or fewer retrieved oocytes were prospectively randomized into two groups.Group I (60 patients) received the microdose flare-up regimen and group II (60 patients) received the ultrashort GNRH AGONIST combined with fixed GNRH ANTAGONIST.Results: There were no significant differences between the groups in the number of used gonadotropin ampoules (p=0.591), duration of stimulation (p=0.610), number of retrieved oocytes (p=0.802), fertilization rate (p=0.456), and the number of transferred embryos (p=0.954). The clinical pregnancy rates were statistically similar in group I (10%) compared with group II (13.3%, p=0.389).Conclusion: According to our results, there is no significant difference between these protocols for improving the ART outcome in POOR RESPONDERs. Additional prospective, randomized studies with more patients is necessary to determine the best protocol (Registration Number: IRCT201105096420N1).

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    Cite

    APA: Copy

    EFTEKHAR, MARYAM, MOHAMMADIAN, FARNAZ, YOUSEFNEJAD, FARIBA, & KHANI, PARISA. (2013). MICRODOSE GNRH AGONIST FLARE-UP VERSUS ULTRASHORT GNRH AGONIST COMBINED WITH FIXED GNRH ANTAGONIST IN POOR RESPONDERS OF ASSISTED REPRODUCTIVE TECHNIQUES CYCLES. INTERNATIONAL JOURNAL OF FERTILITY AND STERILITY, 6(4), 266-271. SID. https://sid.ir/paper/305383/en

    Vancouver: Copy

    EFTEKHAR MARYAM, MOHAMMADIAN FARNAZ, YOUSEFNEJAD FARIBA, KHANI PARISA. MICRODOSE GNRH AGONIST FLARE-UP VERSUS ULTRASHORT GNRH AGONIST COMBINED WITH FIXED GNRH ANTAGONIST IN POOR RESPONDERS OF ASSISTED REPRODUCTIVE TECHNIQUES CYCLES. INTERNATIONAL JOURNAL OF FERTILITY AND STERILITY[Internet]. 2013;6(4):266-271. Available from: https://sid.ir/paper/305383/en

    IEEE: Copy

    MARYAM EFTEKHAR, FARNAZ MOHAMMADIAN, FARIBA YOUSEFNEJAD, and PARISA KHANI, “MICRODOSE GNRH AGONIST FLARE-UP VERSUS ULTRASHORT GNRH AGONIST COMBINED WITH FIXED GNRH ANTAGONIST IN POOR RESPONDERS OF ASSISTED REPRODUCTIVE TECHNIQUES CYCLES,” INTERNATIONAL JOURNAL OF FERTILITY AND STERILITY, vol. 6, no. 4, pp. 266–271, 2013, [Online]. Available: https://sid.ir/paper/305383/en

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