DOES ADDING DEXAMETHASONE TO CLOMIPHENE CITRATE IMPROVE OVULATION IN PCOS PATIENTS? A TRIPLE-BLIND RANDOMIZED CLINICAL TRIAL STUDY

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ESMAEILZADEH SEDDIGHEH; GOLSORKHTABAR AMIRI MASOUMEH; BASIR ZAHRA; SHIRAZI MAHIN

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Journal: International Journal of Fertility & Sterility Year:2011 | Volume:5 | Issue:1 Page(s): 9-12

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Title

DOES ADDING DEXAMETHASONE TO CLOMIPHENE CITRATE IMPROVE OVULATION IN PCOS PATIENTS? A TRIPLE-BLIND RANDOMIZED CLINICAL TRIAL STUDY

Author(s)

ESMAEILZADEH SEDDIGHEH | GOLSORKHTABAR AMIRI MASOUMEH | BASIR ZAHRA | SHIRAZI MAHIN | Issue Writer Certificate

Keywords

PCOS

CLOMIPHENE CITRATE

DEXAMETHASONE

Abstract

Background: A common cause of anovulation is polycystic ovarian syndrome (PCOS). CLOMIPHENE CITRATE (CC) is the first line of treatment in PCOS patients however approximately 25% of patients may be CC-resistant.This study aimed to evaluate the efficacy of adding DEXAMETHASONE (dex) to CC in CC-resistant PCOS patients with the intent to improve ovulation.Materials and Methods: This randomized controlled trial study was performed on 60 infertile PCOS patients referred to our infertility research center from 2007 to 2009. Patients were randomly divided in two groups and stimulation performed with dex+CC or CC+placebo. Rates of ovulation, pregnancy and number of mature follicles were evaluated.Results: Ovulation rate in the dex+CC group was 21 out of 30 (70%) and in the CC+placebo group it was 17 out of 30 (56.7%). The pregnancy rate was 5 (16.7%) in the dex+CC group and 3 (10%) in the CC+placebo group. There was no significant difference between rates of ovulation and pregnancy in both groups, but the number of follicles≥18 mm were significant in the dex+CC group (p<0.05).Conclusion: Our results showed that addition of dex to CC significantly increased the number of matured follicles, however the ovulation and pregnancy rates were comparable between the two groups.

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APA: Copy

ESMAEILZADEH, SEDDIGHEH, GOLSORKHTABAR AMIRI, MASOUMEH, BASIR, ZAHRA, & SHIRAZI, MAHIN. (2011). DOES ADDING DEXAMETHASONE TO CLOMIPHENE CITRATE IMPROVE OVULATION IN PCOS PATIENTS? A TRIPLE-BLIND RANDOMIZED CLINICAL TRIAL STUDY. INTERNATIONAL JOURNAL OF FERTILITY AND STERILITY, 5(1), 9-12. SID. https://sid.ir/paper/304731/en

Vancouver: Copy

ESMAEILZADEH SEDDIGHEH, GOLSORKHTABAR AMIRI MASOUMEH, BASIR ZAHRA, SHIRAZI MAHIN. DOES ADDING DEXAMETHASONE TO CLOMIPHENE CITRATE IMPROVE OVULATION IN PCOS PATIENTS? A TRIPLE-BLIND RANDOMIZED CLINICAL TRIAL STUDY. INTERNATIONAL JOURNAL OF FERTILITY AND STERILITY[Internet]. 2011;5(1):9-12. Available from: https://sid.ir/paper/304731/en

IEEE: Copy

SEDDIGHEH ESMAEILZADEH, MASOUMEH GOLSORKHTABAR AMIRI, ZAHRA BASIR, and MAHIN SHIRAZI, “DOES ADDING DEXAMETHASONE TO CLOMIPHENE CITRATE IMPROVE OVULATION IN PCOS PATIENTS? A TRIPLE-BLIND RANDOMIZED CLINICAL TRIAL STUDY,” INTERNATIONAL JOURNAL OF FERTILITY AND STERILITY, vol. 5, no. 1, pp. 9–12, 2011, [Online]. Available: https://sid.ir/paper/304731/en

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