Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

video

Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

sound

Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Persian Version

Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

View:

405
Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Download:

185
Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Cites:

1

Information Journal Paper

Title

LONG-TERM EFFECT OF CIPROFLOXACIN ON TESTICULAR TISSUE: EVIDENCE FOR BIOCHEMICAL AND HISTOCHEMICAL CHANGES

Pages

  294-303

Abstract

 Background: This research studied the effect of CIPROFLOXACIN (CPFX) on spermatogenesis. We aimed to estimate the effect of CPFX on serum levels of TESTOSTERONE, LH and FSH.Materials and Methods: In this experimental study, a total of 24 mice were assigned to controlsham and test groups. We subdivided the test group into low (206 mg/kg) and high (412 mg/kg) dose CPFX groups. Control-sham animals received carboxymethyl cellulose (CMC). All animals were treated orally for 45 days.Cytoplasmic carbohydrate, LIPID ACCUMULATION, cytoplasmic LIPASE and ALKALINE PHOSPHATASE (ALP) ratios were examined. Serum levels of luteinizing hormone (LH), follicle stimulating hormone (FSH) and TESTOSTERONE were measured in the control and test groups.Results: The spermatogenesis cell series exhibited low numbers of cells with periodic acid Schiff (PAS) -positive cytoplasm and higher numbers of cells with lipid-positive foci. The tissue to ALP ratio and germinal epithelium (GE) LIPASE synthesis increased in CPFX-treated animals. In contrast to the CPFX groups, control animals showed normal cytoplasmic carbohydrate, lipid, LIPASE and ALP ratios in all cellular layers. In the CPFX-treated groups there was a significantly lower serum TESTOSTERONE level compared with the control group. The serum levels of FSH and LH in high dosetreated animals decreased.Conclusion: Our results suggest that following long time CPFX administration major alterations occur in GE intracytoplasmic biochemistry, which may lead to loss of physiological function and ultimately result in fertility problems.CPFX is able to imbalance serum levels of gonadotropins and TESTOSTERONE levels by affecting Leydig cells.

Cites

References

Cite

APA: Copy

ZOBEIRI, FATEMEH, SADRKHANLOU, RAJAB ALI, SALAMI, SIAMAK, & MARDANI, KARIM. (2013). LONG-TERM EFFECT OF CIPROFLOXACIN ON TESTICULAR TISSUE: EVIDENCE FOR BIOCHEMICAL AND HISTOCHEMICAL CHANGES. INTERNATIONAL JOURNAL OF FERTILITY AND STERILITY, 6(4), 294-303. SID. https://sid.ir/paper/305388/en

Vancouver: Copy

ZOBEIRI FATEMEH, SADRKHANLOU RAJAB ALI, SALAMI SIAMAK, MARDANI KARIM. LONG-TERM EFFECT OF CIPROFLOXACIN ON TESTICULAR TISSUE: EVIDENCE FOR BIOCHEMICAL AND HISTOCHEMICAL CHANGES. INTERNATIONAL JOURNAL OF FERTILITY AND STERILITY[Internet]. 2013;6(4):294-303. Available from: https://sid.ir/paper/305388/en

IEEE: Copy

FATEMEH ZOBEIRI, RAJAB ALI SADRKHANLOU, SIAMAK SALAMI, and KARIM MARDANI, “LONG-TERM EFFECT OF CIPROFLOXACIN ON TESTICULAR TISSUE: EVIDENCE FOR BIOCHEMICAL AND HISTOCHEMICAL CHANGES,” INTERNATIONAL JOURNAL OF FERTILITY AND STERILITY, vol. 6, no. 4, pp. 294–303, 2013, [Online]. Available: https://sid.ir/paper/305388/en

Related Journal Papers

  • No record.

    • Related Seminar Papers

  • No record.

    • Related Plans

  • No record.

    • Recommended Workshops






    Move to top