THE NECESSITY OF GENETIC SCREENING IN PREMATURE OVARIAN FAILURE AND DIMINISHED OVARIAN RESERVED PATIENTS

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

MOHSENI MEYBODI A.

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: International Journal of Fertility & Sterility Year:2013 | Volume:7 | Issue:SUPPLEMENT 1 Page(s): 24-25

Download Full-Text

View:

198

Download:

Cites:

Information Journal Paper

Title

THE NECESSITY OF GENETIC SCREENING IN PREMATURE OVARIAN FAILURE AND DIMINISHED OVARIAN RESERVED PATIENTS

Author(s)

MOHSENI MEYBODI A.

Keywords

Not Registered.

Abstract

Variability in the subfertile patient population excludes the possibility of a single approach to controlled ovarian stimulation (COS) covering all the requirements of a patient. Modern medical science has made great advances in the understanding and the development of new drugs, treatment options and quantitative methods that can identify single patient characteristics. Factors that reduce follicle or defect in the follicle growth stimulating mechanism defined as numerous complication factors that they can cause premature ovarian failure (POF) or diminished ovarian reserve (DOR). According to reports several genetic factors considered to cause these conditions. Genes on the X-chromosome and autosomal genes are detected in these disorders too. FMR1 gene that is on X-chromosome is one of the important genes which is related to POF and also DOR. Premutation in this gene are more common in these patients. Subsequently, screening for FMR1 premutations is recommended for the routine work-up for any woman presenting with POF and DOR. The reason for this is these women need to be informed if they are at risk of having a child with fragile X syndrome. In addition, the identification of a family in which the fragile X repeat site is expanded can lead to the identification of other female family members at risk of transmitting fragile X syndrome. Presently, even though the biological response to any given drug may be influenced by hundreds of genes, progress is being made in the identification of specific genetic variances such as SNPs that can predict the safety and effectiveness of certain drugs in individual patients. For example, there are evidences that GDF-9 c.G546A to be correlated with POF, poor ovarian stimulation and in vitro fertilization outcomes in women with DOR. Another possible reason for this hyporesponder population is that they may have a genetic predisposition to a reduced sensitivity to FSH which may also be caused by a genetic variation and polymorphisms of the LH, the FSH receptor or the LH receptor. Moreover, a multigenic model including specific ESR1 and ESR2 genotype patterns may partially explain the poor response to FSH. Besides, the ER-alpha gene polymorphisms may be associated with idiopathic POF too. Thus, genetic testing of women showing reduced sensitivity to FSH may assist in tailoring subsequent treatment. Finally, in the future, genetic screening may allow an individual patient's response to stimulation during COS to be predicted based on genotype. If a patient's genetic profile also diminishes her response to fertility treatment, the failure to consider the genotype when designing the treatment consequently leads to a suboptimal treatment strategy.

Multimedia

No record.

Cites

No record.

References

No record.

Cite

APA: Copy

MOHSENI MEYBODI, A.. (2013). THE NECESSITY OF GENETIC SCREENING IN PREMATURE OVARIAN FAILURE AND DIMINISHED OVARIAN RESERVED PATIENTS. INTERNATIONAL JOURNAL OF FERTILITY AND STERILITY, 7(SUPPLEMENT 1), 24-25. SID. https://sid.ir/paper/305560/en

Vancouver: Copy

MOHSENI MEYBODI A.. THE NECESSITY OF GENETIC SCREENING IN PREMATURE OVARIAN FAILURE AND DIMINISHED OVARIAN RESERVED PATIENTS. INTERNATIONAL JOURNAL OF FERTILITY AND STERILITY[Internet]. 2013;7(SUPPLEMENT 1):24-25. Available from: https://sid.ir/paper/305560/en

IEEE: Copy

A. MOHSENI MEYBODI, “THE NECESSITY OF GENETIC SCREENING IN PREMATURE OVARIAN FAILURE AND DIMINISHED OVARIAN RESERVED PATIENTS,” INTERNATIONAL JOURNAL OF FERTILITY AND STERILITY, vol. 7, no. SUPPLEMENT 1, pp. 24–25, 2013, [Online]. Available: https://sid.ir/paper/305560/en

Related Journal Papers

No record.

Related Seminar Papers

No record.

Related Plans

No record.

Recommended Workshops