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Information Journal Paper

Title

EVALUATION OF TUMOR NECROSIS FACTOR ALPHA POLYMORPHISM FREQUENCIES IN ENDOMETRIOSIS

Pages

  329-337

Abstract

 Background: The pro-inflammatory cytokine, TUMOR NECROSIS FACTOR-alpha (TNF-a), is a pathogenic element for a number of disorders. Previous studies have reported that the -1031 T/C and -238 G/A POLYMORPHISMs in the promoter region of the TNF-a gene are important factors in reproductive-related disorders. One of the most common gynecological diseases of women during the reproductive years is ENDOMETRIOSIS. This study aims to assess an association between the -1031 T/C, -238 G/A and -308 G/A POLYMORPHISMs of the TNF-a gene promoter region to ENDOMETRIOSIS.Materials and Methods: In this case-control study, we enrolled 65 ENDOMETRIOSIS patients and 65 matched healthy control women by simple sampling. Polymerase chain reaction (PCR) analysis was used to analyze -1031 T/C, -238 G/A and -308 G/A POLYMORPHISMs in the TNF-a gene promoter region. Statistical analysis was performed using the chi-square test. P values less than 0.05 were considered statistically significant. Results: We found a strong association between the -1031 T/C POLYMORPHISM in the promoter region of the TNF-a gene with ENDOMETRIOSIS (P=0.001). There were no significant associations between the -238 G/A (P=0.243) and -308 G/A (P=1) POLYMORPHISMs with ENDOMETRIOSIS and again ENDOMETRIOSIS stages have no association with these POLYMORPHISMs. Conclusion: The -1031 T/C POLYMORPHISM and CC genotype can be used as a relevant marker to identify women at risk of developing ENDOMETRIOSIS.

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    Cite

    APA: Copy

    ABUTORABI, ROSHANAK, BARADARAN, AZAR, MOSTAFAVI, FATEMEH SADAT, ZARRIN, YASAMAN, & MARDANIAN, FARAHNAZ. (2015). EVALUATION OF TUMOR NECROSIS FACTOR ALPHA POLYMORPHISM FREQUENCIES IN ENDOMETRIOSIS. INTERNATIONAL JOURNAL OF FERTILITY AND STERILITY, 9(3), 329-337. SID. https://sid.ir/paper/305829/en

    Vancouver: Copy

    ABUTORABI ROSHANAK, BARADARAN AZAR, MOSTAFAVI FATEMEH SADAT, ZARRIN YASAMAN, MARDANIAN FARAHNAZ. EVALUATION OF TUMOR NECROSIS FACTOR ALPHA POLYMORPHISM FREQUENCIES IN ENDOMETRIOSIS. INTERNATIONAL JOURNAL OF FERTILITY AND STERILITY[Internet]. 2015;9(3):329-337. Available from: https://sid.ir/paper/305829/en

    IEEE: Copy

    ROSHANAK ABUTORABI, AZAR BARADARAN, FATEMEH SADAT MOSTAFAVI, YASAMAN ZARRIN, and FARAHNAZ MARDANIAN, “EVALUATION OF TUMOR NECROSIS FACTOR ALPHA POLYMORPHISM FREQUENCIES IN ENDOMETRIOSIS,” INTERNATIONAL JOURNAL OF FERTILITY AND STERILITY, vol. 9, no. 3, pp. 329–337, 2015, [Online]. Available: https://sid.ir/paper/305829/en

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