CORRELATION OF SERUM LIPOPROTEIN RATIOS WITH INSULIN RESISTANCE IN INFERTILE WOMEN WITH POLYCYSTIC OVARIAN SYNDROME: A CASE CONTROL STUDY

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GHAFFARZAD AISA; AMANI REZA; SADAGHIANI MAHZAD MEHRZAD; DARABI MASOUD; CHERAGHIAN BAHMAN

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Journal Paper

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Journal: International Journal of Fertility & Sterility Year:2016 | Volume:10 | Issue:1 Page(s): 29-35

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Title

CORRELATION OF SERUM LIPOPROTEIN RATIOS WITH INSULIN RESISTANCE IN INFERTILE WOMEN WITH POLYCYSTIC OVARIAN SYNDROME: A CASE CONTROL STUDY

Author(s)

Keywords

LIPOPROTEIN

INFERTILITY

PCOS

INSULIN RESISTANCE

Abstract

Background: Dyslipidemia and INSULIN RESISTANCE (IR), occurring in most infertile women with polycystic ovarian syndrome (PCOS), increase the risk of cardiovascular disease (CVD) and type 2 diabetes. This study aimed to assess the relationships between LIPOPROTEIN ratios and IR in PCOS women.Materials and Methods: Thirty six infertile women with PCOS selected based on Androgen Excess Society (AES) criteria and 29 healthy women matched for age were recruited to this case-control study. After physical measurements, fasting serum glucose (Glu), insulin and lipid profile levels [triglycerides (TGs), total cholesterol (TC), low-density LIPOPROTEIN cholesterol (LDL-C) and high-density LIPOPROTEIN-cholesterol (HDL-C)] were measured, while LIPOPROTEIN ratios (TC/HDL-C, LDL-C/HDL-C, TG/HDL-C) were calculated. IR was also calculated using homeostasis model assessment (HOMA)-IR. The optimal cutoffs of LIPOPROTEIN ratios in relation to HOMA-IR were calculated based on the Receiver Operating Characteristics (ROC) curve analysis using the area under curve (AUC).Results: Waist circumference (WC), insulin levels, HOMA-IR, TG levels, and all LIPOPROTEIN ratios were significantly higher, while HDL-C was lower in PCOS group as compared to healthy controls. All LIPOPROTEIN ratios, TG levels, and WC are significantly correlated with insulin levels and HOMA-IR. Among LIPOPROTEIN ratios, the highest AUC of the ROC belonged to TG/HDL-C ratio with sensitivity of 63.6% and specificity of 84.4% (TG/HDL-C>3.19) as a marker of IR in infert ile PCOS women.Conclusion: LIPOPROTEIN ratios, particularly TG/HDL-C, are directly correlated with insulin levels and can be used as a marker of IR (HOMA-IR) in infertile PCOS patients.

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APA: Copy

GHAFFARZAD, AISA, AMANI, REZA, SADAGHIANI, MAHZAD MEHRZAD, DARABI, MASOUD, & CHERAGHIAN, BAHMAN. (2016). CORRELATION OF SERUM LIPOPROTEIN RATIOS WITH INSULIN RESISTANCE IN INFERTILE WOMEN WITH POLYCYSTIC OVARIAN SYNDROME: A CASE CONTROL STUDY. INTERNATIONAL JOURNAL OF FERTILITY AND STERILITY, 10(1), 29-35. SID. https://sid.ir/paper/305862/en

Vancouver: Copy

GHAFFARZAD AISA, AMANI REZA, SADAGHIANI MAHZAD MEHRZAD, DARABI MASOUD, CHERAGHIAN BAHMAN. CORRELATION OF SERUM LIPOPROTEIN RATIOS WITH INSULIN RESISTANCE IN INFERTILE WOMEN WITH POLYCYSTIC OVARIAN SYNDROME: A CASE CONTROL STUDY. INTERNATIONAL JOURNAL OF FERTILITY AND STERILITY[Internet]. 2016;10(1):29-35. Available from: https://sid.ir/paper/305862/en

IEEE: Copy

AISA GHAFFARZAD, REZA AMANI, MAHZAD MEHRZAD SADAGHIANI, MASOUD DARABI, and BAHMAN CHERAGHIAN, “CORRELATION OF SERUM LIPOPROTEIN RATIOS WITH INSULIN RESISTANCE IN INFERTILE WOMEN WITH POLYCYSTIC OVARIAN SYNDROME: A CASE CONTROL STUDY,” INTERNATIONAL JOURNAL OF FERTILITY AND STERILITY, vol. 10, no. 1, pp. 29–35, 2016, [Online]. Available: https://sid.ir/paper/305862/en

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