A PRELIMINARY STUDY: N-ACETYL-L-CYSTEINE IMPROVES SEMEN QUALITY FOLLOWING VARICOCELECTOMY

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BAREKAT FOROOGH; TAVALAEE MARZIYEH; DEEMEH MOHAMMAD REZA; BAHREINIAN MAHSA; AZADI LEILA; ABBASI HOMAYOUN; ROZBAHANI SHAHLA; NASR ESFAHANI MOHAMMAD HOSSEIN

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Journal: International Journal of Fertility & Sterility Year:2016 | Volume:10 | Issue:1 Page(s): 120-126

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Title

A PRELIMINARY STUDY: N-ACETYL-L-CYSTEINE IMPROVES SEMEN QUALITY FOLLOWING VARICOCELECTOMY

Author(s)

Keywords

DNA FRAGMENTATION

PROTAMINES

OXIDATIVE STRESS

VARICOCELE

NAC

Abstract

Background: Surgery is considered the primary treatment for male infertility from clinical VARICOCELE. One of the main events associated with VARICOCELE is excessive production of reactive oxygen species (ROS). N-acetyl-L-cysteine (NAC), an antioxidant that scavenges free radicals, is considered a supplement to alleviate glutathione (GSH) depletion during OXIDATIVE STRESS. Despite beneficial effects of NAC in other pathological events, there is no report on the effect of NAC in individuals with VARICOCELE. Therefore, the aim of this study is to evaluate the outcome of NAC on semen quality, protamine content, DNA damage, OXIDATIVE STRESS and fertility following VARICOCELEctomy.Materials and Methods: This prospective clinical trial included 35 infertile men with VARICOCELE randomly divided into control (n=20) and NAC (n=15) groups. We assessed semen parameters, protamine content [chromomycin A3 (CMA3)], DNA integrity [terminal deoxynucleotidyltransferase-mediated dUTP nick-end labeling (TUNEL)] and OXIDATIVE STRESS [2, 7-dichlorodihydrofluorescein-diacetate (DCFH-DA)] before and three months after VARICOCELEctomy.Results: Percentage of abnormal semen parameters, protamine deficiency, DNA FRAGMENTATION and OXIDATIVE STRESS were significantly decreased in both groups compared to before surgery. We calculated the percentage of improvement in these parameters compared to before surgery for each group, then compared the results between the groups. Only percentage of protamine deficiency and DNA FRAGMENTATION significantly differed between the NAC and control groups.Conclusion: The results of this study, for the first time, revealed that NAC improved chromatin integrity and pregnancy rate when administered as adjunct therapy post-varicocelectomy (Registeration Number: IRCT201508177223N5).

Cites

Relationship between Sperm Parameters with Sperm Function Tests in Infertile Men with at Least One Failed Cycle after Intracytoplasmic Sperm Injection Cycle

References

EFFECT OF VARICOCELEDOMY ON SEMEN PARAMETERS AND SPERM CHROMATIN STATUS

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APA: Copy

BAREKAT, FOROOGH, TAVALAEE, MARZIYEH, DEEMEH, MOHAMMAD REZA, BAHREINIAN, MAHSA, AZADI, LEILA, ABBASI, HOMAYOUN, ROZBAHANI, SHAHLA, & NASR ESFAHANI, MOHAMMAD HOSSEIN. (2016). A PRELIMINARY STUDY: N-ACETYL-L-CYSTEINE IMPROVES SEMEN QUALITY FOLLOWING VARICOCELECTOMY. INTERNATIONAL JOURNAL OF FERTILITY AND STERILITY, 10(1), 120-126. SID. https://sid.ir/paper/305867/en

Vancouver: Copy

BAREKAT FOROOGH, TAVALAEE MARZIYEH, DEEMEH MOHAMMAD REZA, BAHREINIAN MAHSA, AZADI LEILA, ABBASI HOMAYOUN, ROZBAHANI SHAHLA, NASR ESFAHANI MOHAMMAD HOSSEIN. A PRELIMINARY STUDY: N-ACETYL-L-CYSTEINE IMPROVES SEMEN QUALITY FOLLOWING VARICOCELECTOMY. INTERNATIONAL JOURNAL OF FERTILITY AND STERILITY[Internet]. 2016;10(1):120-126. Available from: https://sid.ir/paper/305867/en

IEEE: Copy

FOROOGH BAREKAT, MARZIYEH TAVALAEE, MOHAMMAD REZA DEEMEH, MAHSA BAHREINIAN, LEILA AZADI, HOMAYOUN ABBASI, SHAHLA ROZBAHANI, and MOHAMMAD HOSSEIN NASR ESFAHANI, “A PRELIMINARY STUDY: N-ACETYL-L-CYSTEINE IMPROVES SEMEN QUALITY FOLLOWING VARICOCELECTOMY,” INTERNATIONAL JOURNAL OF FERTILITY AND STERILITY, vol. 10, no. 1, pp. 120–126, 2016, [Online]. Available: https://sid.ir/paper/305867/en

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