CROCIN IMPROVES DAMAGE INDUCED BY NICOTINE ON A NUMBER OF REPRODUCTIVE PARAMETERS IN MALE MICE

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SALAHSHOOR MOHAMMAD REZA; KHAZAEI MOZAFAR; JALILI CYRUS; KEIVAN MONA

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Journal Paper

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Journal: International Journal of Fertility & Sterility Year:2016 | Volume:10 | Issue:1 Page(s): 71-78

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Title

CROCIN IMPROVES DAMAGE INDUCED BY NICOTINE ON A NUMBER OF REPRODUCTIVE PARAMETERS IN MALE MICE

Author(s)

SALAHSHOOR MOHAMMAD REZA | KHAZAEI MOZAFAR | JALILI CYRUS | KEIVAN MONA | Issue Writer Certificate

Keywords

CROCIN

NICOTINE

DAMAGE

REPRODUCTIVE

Abstract

Background: CROCIN, a carotenoid isolated from Crocus sativus L. (saffron), is a pharmacologically active component of saffron. NICOTINE consumption can decrease fertility in males through induction of oxidative stress and DNA DAMAGE. The aim of this study is to determine the effects of CROCIN on REPRODUCTIVE parameter DAMAGEs in male mice exposed to NICOTINE.Materials and Methods: In this experimental study, we divided 48 mice into 8 groups (n=6 per group): control (normal saline), NICOTINE (2.5 mg/kg), CROCIN (12.5, 25 and 50 mg/kg) and CROCIN (12.5, 25 and 50 mg/kg)+nicotine (2.5 mg/kg). Mice received once daily intraperitoneal injections of CROCIN, NICOTINE and CROCIN+nicotine for 4 weeks. Sperm parameters (count, motility, and viability), testis weight, seminiferous tube diameters, testosterone, and serum nitric oxide levels were analyzed and compared.Results: NICOTINE administration significantly decreased testosterone level; sperm count, viability, and motility; testis weight and seminiferous tubule diameters compared to the control group (P<0.05). However, increasing the dose of CROCIN in the CROCIN and CROCIN+nicotine groups significantly boosted sperm motility and viability; seminiferous tubule diameters; testis weight; and testosterone levels in all groups compared to the NICOTINE group (P<0.05).Conclusion: CROCIN improves NICOTINE-induced adverse effects on REPRODUCTIVE parameters in male mice.

Cites

The effect of crocin on testicular tissue and sperm parameters of mice offspring from mothers exposed to atrazine during pregnancy and lactation periods: An experimental study

References

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APA: Copy

SALAHSHOOR, MOHAMMAD REZA, KHAZAEI, MOZAFAR, JALILI, CYRUS, & KEIVAN, MONA. (2016). CROCIN IMPROVES DAMAGE INDUCED BY NICOTINE ON A NUMBER OF REPRODUCTIVE PARAMETERS IN MALE MICE. INTERNATIONAL JOURNAL OF FERTILITY AND STERILITY, 10(1), 71-78. SID. https://sid.ir/paper/305873/en

Vancouver: Copy

SALAHSHOOR MOHAMMAD REZA, KHAZAEI MOZAFAR, JALILI CYRUS, KEIVAN MONA. CROCIN IMPROVES DAMAGE INDUCED BY NICOTINE ON A NUMBER OF REPRODUCTIVE PARAMETERS IN MALE MICE. INTERNATIONAL JOURNAL OF FERTILITY AND STERILITY[Internet]. 2016;10(1):71-78. Available from: https://sid.ir/paper/305873/en

IEEE: Copy

MOHAMMAD REZA SALAHSHOOR, MOZAFAR KHAZAEI, CYRUS JALILI, and MONA KEIVAN, “CROCIN IMPROVES DAMAGE INDUCED BY NICOTINE ON A NUMBER OF REPRODUCTIVE PARAMETERS IN MALE MICE,” INTERNATIONAL JOURNAL OF FERTILITY AND STERILITY, vol. 10, no. 1, pp. 71–78, 2016, [Online]. Available: https://sid.ir/paper/305873/en

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