ASSOCIATION OF CYP1A1*2A POLYMORPHISM WITH IDIOPATHIC NON-OBSTRUCTIVE AZOOSPERMIA IN A SOUTH INDIAN COHORT

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RAMGIR SHALAKA S.; SEKAR NISHU; JINDAM DIVYA; ABILASH V.G.

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Journal: International Journal of Fertility & Sterility Year:2017 | Volume:11 | Issue:3 Page(s): 142-147

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Title

ASSOCIATION OF CYP1A1*2A POLYMORPHISM WITH IDIOPATHIC NON-OBSTRUCTIVE AZOOSPERMIA IN A SOUTH INDIAN COHORT

Author(s)

RAMGIR SHALAKA S. | SEKAR NISHU | JINDAM DIVYA | ABILASH V.G. | Issue Writer Certificate

Keywords

CYP1A1

RESTRICTION FRAGMENT LENGTH POLYMORPHISM

INFERTILITY

COHORT

Abstract

Background: INFERTILITY is the inability of a couple to conceive after one and a half years of unprotected sex. Male INFERTILITY, which accounts for almost half of INFERTILITY cases, is considered as a major problem all over the world. The aim of this study was to investigate the association of CYP1A1 polymorphisms with idiopathic non-obstructive azoospermia in a South Indian COHORT.Materials and Methods: An experimental study was conducted with idiopathic nonobstructive azoospermia. A total of 120 infertile and 80 fertile samples were collected, and DNA was then extracted from all samples. The CYP1A1*2A polymorphism genotyping was carried out by polymerase chain reaction (PCR) and RESTRICTION FRAGMENT LENGTH POLYMORPHISM (RFLP).Results: The genotype distribution of CYP1A1*2A polymorphism showed significant difference between patients and controls. Moreover, the CC genotype was associated with decreased risk of idiopathic non-obstructive azoospermia in comparison with the TT and TC genotypes.Conclusion: The current experimental study identified that the CT genotype of CYP1A1*2A polymorphism may contribute to the pathogenesis of male INFERTILITY in the South Indian population.

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APA: Copy

RAMGIR, SHALAKA S., SEKAR, NISHU, JINDAM, DIVYA, & ABILASH, V.G.. (2017). ASSOCIATION OF CYP1A1*2A POLYMORPHISM WITH IDIOPATHIC NON-OBSTRUCTIVE AZOOSPERMIA IN A SOUTH INDIAN COHORT. INTERNATIONAL JOURNAL OF FERTILITY AND STERILITY, 11(3), 142-147. SID. https://sid.ir/paper/305932/en

Vancouver: Copy

RAMGIR SHALAKA S., SEKAR NISHU, JINDAM DIVYA, ABILASH V.G.. ASSOCIATION OF CYP1A1*2A POLYMORPHISM WITH IDIOPATHIC NON-OBSTRUCTIVE AZOOSPERMIA IN A SOUTH INDIAN COHORT. INTERNATIONAL JOURNAL OF FERTILITY AND STERILITY[Internet]. 2017;11(3):142-147. Available from: https://sid.ir/paper/305932/en

IEEE: Copy

SHALAKA S. RAMGIR, NISHU SEKAR, DIVYA JINDAM, and V.G. ABILASH, “ASSOCIATION OF CYP1A1*2A POLYMORPHISM WITH IDIOPATHIC NON-OBSTRUCTIVE AZOOSPERMIA IN A SOUTH INDIAN COHORT,” INTERNATIONAL JOURNAL OF FERTILITY AND STERILITY, vol. 11, no. 3, pp. 142–147, 2017, [Online]. Available: https://sid.ir/paper/305932/en

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