MULTIPLEX-POLYMERASE CHAIN REACTION FOR DETECTING MICRO DELETIONS IN THE AZOOSPERMIA FACTOR REGION OF Y CHROMOSOME IN IRANIAN COUPLES WITH NON-OBSTRUCTIVE INFERTILITY AND RECURRENT PREGNANCY LOSS

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MOJTABANEZHAD SHARIATPANAHI AFSANEH; AHMADNIA HASSAN; TORKAMANZEHI ADAM; MANSOURI TORSHIZI MAHNAZ; KERACHIAN MOHAMMAD AMIN

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Journal: International Journal of Fertility & Sterility Year:2018 | Volume:11 | Issue:4 Page(s): 253-257

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Title

MULTIPLEX-POLYMERASE CHAIN REACTION FOR DETECTING MICRO DELETIONS IN THE AZOOSPERMIA FACTOR REGION OF Y CHROMOSOME IN IRANIAN COUPLES WITH NON-OBSTRUCTIVE INFERTILITY AND RECURRENT PREGNANCY LOSS

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Keywords

INFERTILITY

MULTIPLEX POLYMERASE CHAIN REACTION

Y CHROMOSOME

Abstract

Background: Approximately 15% of couples are infertile with the male factor explaining approximately 50% of the cases. One of the main genetic factors playing a role in male INFERTILITY is Y chromosomal micro deletions within the proximal long arm of the Y CHROMOSOME (Yq11), named the azoospermia factor (AZF) region. Recent studies have shown there is a potential connection between deletions of the AZF region and recurrent pregnancy loss (RPL). The aim of this study is to examine this association by characterizing AZF micro deletions in two infertile groups: in men with non-obstructive INFERTILITY and in men with wives displaying RPL.Materials and Methods: In this is a case-control study, genomic DNA was extracted from 80 male samples including 40 non-obstructive infertile men, 20 males from couples with RPL and 20 fertile males as controls. MULTIPLEX POLYMERASE CHAIN REACTION was used to amplify 19 sequence tagged sites (STS) to detect AZF micro deletions. Differences between the case and control groups were evaluated by two-tailed unpaired t test. P<0.05 were considered statistically significant.Results: Only one subject was detected to have Y CHROMOSOME micro deletions in SY254, SY157 and SY255 among the 40 men with non-obstructive INFERTILITY. No micro deletion was detected in the males with wives displaying RPL and in 20 control males. Y CHROMOSOME micro deletion was neither significantly associated with non-obstructive INFERTILITY (P=0.48) nor with recurrent pregnancy loss.Conclusion: Performing Testing for Y CHROMOSOME micro deletions in men with non-obstructive INFERTILITY and couples with RPL remains inconclusive in this study.

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APA: Copy

MOJTABANEZHAD SHARIATPANAHI, AFSANEH, AHMADNIA, HASSAN, TORKAMANZEHI, ADAM, MANSOURI TORSHIZI, MAHNAZ, & KERACHIAN, MOHAMMAD AMIN. (2018). MULTIPLEX-POLYMERASE CHAIN REACTION FOR DETECTING MICRO DELETIONS IN THE AZOOSPERMIA FACTOR REGION OF Y CHROMOSOME IN IRANIAN COUPLES WITH NON-OBSTRUCTIVE INFERTILITY AND RECURRENT PREGNANCY LOSS. INTERNATIONAL JOURNAL OF FERTILITY AND STERILITY, 11(4), 253-257. SID. https://sid.ir/paper/305951/en

Vancouver: Copy

MOJTABANEZHAD SHARIATPANAHI AFSANEH, AHMADNIA HASSAN, TORKAMANZEHI ADAM, MANSOURI TORSHIZI MAHNAZ, KERACHIAN MOHAMMAD AMIN. MULTIPLEX-POLYMERASE CHAIN REACTION FOR DETECTING MICRO DELETIONS IN THE AZOOSPERMIA FACTOR REGION OF Y CHROMOSOME IN IRANIAN COUPLES WITH NON-OBSTRUCTIVE INFERTILITY AND RECURRENT PREGNANCY LOSS. INTERNATIONAL JOURNAL OF FERTILITY AND STERILITY[Internet]. 2018;11(4):253-257. Available from: https://sid.ir/paper/305951/en

IEEE: Copy

AFSANEH MOJTABANEZHAD SHARIATPANAHI, HASSAN AHMADNIA, ADAM TORKAMANZEHI, MAHNAZ MANSOURI TORSHIZI, and MOHAMMAD AMIN KERACHIAN, “MULTIPLEX-POLYMERASE CHAIN REACTION FOR DETECTING MICRO DELETIONS IN THE AZOOSPERMIA FACTOR REGION OF Y CHROMOSOME IN IRANIAN COUPLES WITH NON-OBSTRUCTIVE INFERTILITY AND RECURRENT PREGNANCY LOSS,” INTERNATIONAL JOURNAL OF FERTILITY AND STERILITY, vol. 11, no. 4, pp. 253–257, 2018, [Online]. Available: https://sid.ir/paper/305951/en

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