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Information Journal Paper

Title

SCREENING FOR CAUSATIVE MUTATIONS OF MAJOR PROLIFICACY GENES IN IRANIAN FAT-TAILED SHEEP

Pages

  51-55

Abstract

 Background: The presence of different missense mutations in SHEEP breeds have shown that the bone morphogenetic protein receptor 1B (BMPR1B), bone morphogenetic protein 15 (BMP15) and growth differentiation factor 9 (GDF9)genes play a vital role in ovulation rate and prolificacy in ewes. Therefore, the present study aims to investigate BMPR1B, BMP15 and GDF9 gene mutations in prolific ewes of Iranian fat-tailed Lori-Bakhtiari SHEEP.Materials and Methods: In the present experimental study, genomic DNA was extracted from whole blood of 10prolific Lori-Bakhtiari ewes with at least two twinning records in the first four parities to identify point mutations of the BMPR1B, BMP15 and GDF9 genes, using DNA sequencing.Results: The results obtained from DNA sequencing showed a new synonymous mutation (g.66496G>A) in exon 8of the BMPR1B gene, without any amino acid change. Sequencing of the BMP15 gene revealed a deletion of 3 bp (g.656_658delTTC) in exon 1, leading to an amino acid deletion (p.Leu19del). Four SINGLE NUCLEOTIDE POLYMORPHISMs (G1: g.2118G>A, G2: g.3451T>C, G3: g.3457A>G and G4: g.3701G>A), were detected in exons 1 and 2 of the GDF9gene, two of which caused amino acid substitutions (G1: p.87Arg>His and G4: p.241Glu>Lys). These amino acid alterations are proposed to have a benign impact on structure and function of the GDF9 polypeptide sequence.Conclusion: Three major prolificacy genes (BMPR1B, BMP15 and GDF9) were polymorphic in Lori-Bakhtiari SHEEP, although none of the major causative mutation was detected in this SHEEP type. Further studies using high throughput methods such as genome-wide association study (GWAS) and evaluation of other candidate genes are necessary in the future.

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    APA: Copy

    Abdoli, Ramin, MIRHOSEINI, SEYEDZIAEDDIN, GHAVI HOSSEIN ZADEH, NAVID, & ZAMANI, POUYA. (2018). SCREENING FOR CAUSATIVE MUTATIONS OF MAJOR PROLIFICACY GENES IN IRANIAN FAT-TAILED SHEEP. INTERNATIONAL JOURNAL OF FERTILITY AND STERILITY, 12(1), 51-55. SID. https://sid.ir/paper/305965/en

    Vancouver: Copy

    Abdoli Ramin, MIRHOSEINI SEYEDZIAEDDIN, GHAVI HOSSEIN ZADEH NAVID, ZAMANI POUYA. SCREENING FOR CAUSATIVE MUTATIONS OF MAJOR PROLIFICACY GENES IN IRANIAN FAT-TAILED SHEEP. INTERNATIONAL JOURNAL OF FERTILITY AND STERILITY[Internet]. 2018;12(1):51-55. Available from: https://sid.ir/paper/305965/en

    IEEE: Copy

    Ramin Abdoli, SEYEDZIAEDDIN MIRHOSEINI, NAVID GHAVI HOSSEIN ZADEH, and POUYA ZAMANI, “SCREENING FOR CAUSATIVE MUTATIONS OF MAJOR PROLIFICACY GENES IN IRANIAN FAT-TAILED SHEEP,” INTERNATIONAL JOURNAL OF FERTILITY AND STERILITY, vol. 12, no. 1, pp. 51–55, 2018, [Online]. Available: https://sid.ir/paper/305965/en

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