DETECTION OF Y CHROMOSOME MICRODELETIONS AND HORMONAL PROFILE ANALYSIS OF INFERTILE MEN UNDERGOING ASSISTED REPRODUCTIVE TECHNOLOGIES

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BAHMANIMEHR ARDESHIR; ZEIGHAMI SHAHRYAR; NAMAVAR JAHROMI BAHIA; ANVAR ZAHRA; PARSANEZHAD MOHAMMAD EBRAHIM; DAVARI MARYAM; MONTAZERI SOMAYEH; MOEIN VAZIRI NAJMEH; ZAREI AFSOON

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Journal: International Journal of Fertility & Sterility Year:2018 | Volume:12 | Issue:2 Page(s): 173-177

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Title

DETECTION OF Y CHROMOSOME MICRODELETIONS AND HORMONAL PROFILE ANALYSIS OF INFERTILE MEN UNDERGOING ASSISTED REPRODUCTIVE TECHNOLOGIES

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Keywords

ASSISTED REPRODUCTIVE TECHNOLOGIES

NON-OBSTRUCTIVE AZOOSPERMIA

Y CHROMOSOME DELETION

Abstract

Background: Y CHROMOSOME DELETIONs (YCDs) in azoospermia factor (AZF) region are associated with abnormal spermatogenesis and may lead to azoospermia or severe oligozoospermia. ASSISTED REPRODUCTIVE TECHNOLOGIES (ART) by intracytoplasmic sperm injection (ICSI) and testicular sperm extraction (TESE) are commonly required for infertility management of patients carrying YCDs. The aim of this study was to estimate the frequency of YCDs, to find the most frequent variant in infertile men candidate for ART and to compare YCD distribution with a control fertile group. The semen parameters, hormonal profiles and ART outcomes of the infertile group were studied.Materials and Methods: This case-control study consisted of 97 oligozoospermic or non-obstructive azoospermic (NOA) infertile men, who had undergone ART, as the case group and 100 fertile men as the control group. DNA samples were extracted from blood samples taken from all 197 participants and YCDs were identified by multiplex polymerase chain reaction (PCR) of eight known sequence-tagged sites. The chi-square test was used to compare the mean values of hormone and sperm parameters between the two groups. P<0.05 was considered statistically significant.Results: No YCD was detected in the control group. However, 20 out of 97 (20.6%) infertile men had a YCD. AZFc, AZFbc and AZFabc deletions were detected in 15 (75%), four (20%) and one (5%) YCD-positive patients. No fertilization or clinical pregnancy was seen following ICSI in this sub-group with YCD. The mean level of FSH was significantly higher in the group with YCD (28.45±22.2 vs.4.8±3.17 and 10.83±7.23 in YCD-negative patients with and without clinical pregnancy respectively).Conclusion: YCD is frequent among NOA men and YCD screening before ART and patient counseling is thus strongly recommended.

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APA: Copy

BAHMANIMEHR, ARDESHIR, ZEIGHAMI, SHAHRYAR, NAMAVAR JAHROMI, BAHIA, ANVAR, ZAHRA, PARSANEZHAD, MOHAMMAD EBRAHIM, DAVARI, MARYAM, MONTAZERI, SOMAYEH, MOEIN VAZIRI, NAJMEH, & ZAREI, AFSOON. (2018). DETECTION OF Y CHROMOSOME MICRODELETIONS AND HORMONAL PROFILE ANALYSIS OF INFERTILE MEN UNDERGOING ASSISTED REPRODUCTIVE TECHNOLOGIES. INTERNATIONAL JOURNAL OF FERTILITY AND STERILITY, 12(2), 173-177. SID. https://sid.ir/paper/305990/en

Vancouver: Copy

BAHMANIMEHR ARDESHIR, ZEIGHAMI SHAHRYAR, NAMAVAR JAHROMI BAHIA, ANVAR ZAHRA, PARSANEZHAD MOHAMMAD EBRAHIM, DAVARI MARYAM, MONTAZERI SOMAYEH, MOEIN VAZIRI NAJMEH, ZAREI AFSOON. DETECTION OF Y CHROMOSOME MICRODELETIONS AND HORMONAL PROFILE ANALYSIS OF INFERTILE MEN UNDERGOING ASSISTED REPRODUCTIVE TECHNOLOGIES. INTERNATIONAL JOURNAL OF FERTILITY AND STERILITY[Internet]. 2018;12(2):173-177. Available from: https://sid.ir/paper/305990/en

IEEE: Copy

ARDESHIR BAHMANIMEHR, SHAHRYAR ZEIGHAMI, BAHIA NAMAVAR JAHROMI, ZAHRA ANVAR, MOHAMMAD EBRAHIM PARSANEZHAD, MARYAM DAVARI, SOMAYEH MONTAZERI, NAJMEH MOEIN VAZIRI, and AFSOON ZAREI, “DETECTION OF Y CHROMOSOME MICRODELETIONS AND HORMONAL PROFILE ANALYSIS OF INFERTILE MEN UNDERGOING ASSISTED REPRODUCTIVE TECHNOLOGIES,” INTERNATIONAL JOURNAL OF FERTILITY AND STERILITY, vol. 12, no. 2, pp. 173–177, 2018, [Online]. Available: https://sid.ir/paper/305990/en

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