HISTOPATHOLOGICAL EFFECTS OF TITANIUM DIOXIDE NANOPARTICLES AND THE POSSIBLE PROTECTIVE ROLE OF N-ACETYLCYSTEINE ON THE TESTES OF MALE ALBINO RATS

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BASSAM ELNAGAR AMIR M.; IBRAHIM ABDELNASSER; SOLIMAN AMRO MOHAMED

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Journal: International Journal of Fertility & Sterility Year:2018 | Volume:12 | Issue:3 Page(s): 249-256

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Title

HISTOPATHOLOGICAL EFFECTS OF TITANIUM DIOXIDE NANOPARTICLES AND THE POSSIBLE PROTECTIVE ROLE OF N-ACETYLCYSTEINE ON THE TESTES OF MALE ALBINO RATS

Author(s)

BASSAM ELNAGAR AMIR M. | IBRAHIM ABDELNASSER | SOLIMAN AMRO MOHAMED | Issue Writer Certificate

Keywords

N-ACETYLCYSTEINE

OXIDATIVE STRESS

TESTIS

TITANIUM DIOXIDE

TOXICITY

Abstract

Background: TITANIUM DIOXIDE (TiO2) is a white pigment which is used in paints, plastics, etc. It is reported that TiO2 induces OXIDATIVE STRESS and DNA damage. N-ACETYLCYSTEINE (NAC) has been used to fight OXIDATIVE STRESS-induced damage in different tissues. The objective of this study was to evaluate the toxic effects of orally administered TiO2 nanoparticles and the possible protective effect of NAC on the testes of adult male albino rats.Materials and Methods: In this experimental study, 50 adult male albino rats were classified into five groups. Group I was the negative control, group II was treated with gum acacia solution, group III was treated with NAC, group IV was treated with TiO2 nanoparticles, and group V was treated with 100 mg/kg of NAC and 1200 mg/kg TiO2 nanoparticles. Total testosterone, glutathione (GSH), and serum malondialdehyde (MDA) levels were estimated. The testes were subjected to histopathological, electron microscopic examinations, and immunohistochemical detection for tumor necrosis factor (TNF) -a. Cells from the left TESTIS were examined to detect the degree of DNA impairment by using the comet assay.Results: TiO2 nanoparticles induced histopathological and ultrastructure changes in the testes as well as positive TNF-a immunoreaction in the testicular tissue. Moreover, there was an increase in serum MDA while a decrease in testosterone and GSH levels in TiO2 nanoparticles-treated group. TiO2 resulted in DNA damage. Administration of NAC to TiO2-treated rats led to improvement of the previous parameters with modest protective effects against DNA damage.Conclusion: TiO2-induced damage to the testes was mediated by OXIDATIVE STRESS. Notably, administration of NAC protected against TiO2’s damaging effects.

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APA: Copy

BASSAM ELNAGAR, AMIR M., IBRAHIM, ABDELNASSER, & SOLIMAN, AMRO MOHAMED. (2018). HISTOPATHOLOGICAL EFFECTS OF TITANIUM DIOXIDE NANOPARTICLES AND THE POSSIBLE PROTECTIVE ROLE OF N-ACETYLCYSTEINE ON THE TESTES OF MALE ALBINO RATS. INTERNATIONAL JOURNAL OF FERTILITY AND STERILITY, 12(3), 249-256. SID. https://sid.ir/paper/306002/en

Vancouver: Copy

BASSAM ELNAGAR AMIR M., IBRAHIM ABDELNASSER, SOLIMAN AMRO MOHAMED. HISTOPATHOLOGICAL EFFECTS OF TITANIUM DIOXIDE NANOPARTICLES AND THE POSSIBLE PROTECTIVE ROLE OF N-ACETYLCYSTEINE ON THE TESTES OF MALE ALBINO RATS. INTERNATIONAL JOURNAL OF FERTILITY AND STERILITY[Internet]. 2018;12(3):249-256. Available from: https://sid.ir/paper/306002/en

IEEE: Copy

AMIR M. BASSAM ELNAGAR, ABDELNASSER IBRAHIM, and AMRO MOHAMED SOLIMAN, “HISTOPATHOLOGICAL EFFECTS OF TITANIUM DIOXIDE NANOPARTICLES AND THE POSSIBLE PROTECTIVE ROLE OF N-ACETYLCYSTEINE ON THE TESTES OF MALE ALBINO RATS,” INTERNATIONAL JOURNAL OF FERTILITY AND STERILITY, vol. 12, no. 3, pp. 249–256, 2018, [Online]. Available: https://sid.ir/paper/306002/en

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