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Title

UROCORTIN EXPRESSION IN ENDOMETRIOSIS: A SYSTEMATIC REVIEW

Pages

  1-5

Abstract

 Urocortin (UCN) is a neuropeptide that belongs to the corticotrophin-releasing hormone family and is expressed byeutopic and ectopic human endometria. The past years, this expression has been thoroughly investigated in the fieldof ENDOMETRIOSIS. The objective of this systematic review is to accumulate current evidence related to the expressionof UCN in tissue and blood samples of patients suffering from ENDOMETRIOSIS. Literature search was designed accordingto the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines and primarilyconducted using the Medline (1966-2018), Scopus (2004-2018), EMBASE (1947-2018) and Clinicaltrials. gov (2008-2018) databases, along with the reference lists of electronically retrieved full-text papers. Overall, eight studies wereretrieved. Current evidence suggests that the expression of UCN is increased in patients with ovarian ENDOMETRIOMAsand that its levels may correlate with the severity of the disease. The diagnostic efficacy of UCN1 plasma levels wasevaluated in three studies. Two of them suggested that the sensitivity and specificity of the method may reach, andeven exceed, 80%. However, the wide variation in outcome reporting and outcome reporting measures in ENDOMETRIOSISamong the included studies precludes meta-analysis of available data. Therefore, although UCN seems to be apromising biomarker for the identification and follow-up of patients that suffer from ENDOMETRIOSIS, more studies areneeded to reach firm conclusions with respect to its predictive accuracy.

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    APA: Copy

    PERGIALIOTIS, VASILIOS, TAGKOU, NIKOLETTA MARIA, TSIMPIKTSIOGLOU, ATHINA, KLAVDIANOU, OLGA, NEONAKI, ANTONIA, & TROMPOUKIS, PANTELIS. (2019). UROCORTIN EXPRESSION IN ENDOMETRIOSIS: A SYSTEMATIC REVIEW. INTERNATIONAL JOURNAL OF FERTILITY AND STERILITY, 13(1), 1-5. SID. https://sid.ir/paper/306025/en

    Vancouver: Copy

    PERGIALIOTIS VASILIOS, TAGKOU NIKOLETTA MARIA, TSIMPIKTSIOGLOU ATHINA, KLAVDIANOU OLGA, NEONAKI ANTONIA, TROMPOUKIS PANTELIS. UROCORTIN EXPRESSION IN ENDOMETRIOSIS: A SYSTEMATIC REVIEW. INTERNATIONAL JOURNAL OF FERTILITY AND STERILITY[Internet]. 2019;13(1):1-5. Available from: https://sid.ir/paper/306025/en

    IEEE: Copy

    VASILIOS PERGIALIOTIS, NIKOLETTA MARIA TAGKOU, ATHINA TSIMPIKTSIOGLOU, OLGA KLAVDIANOU, ANTONIA NEONAKI, and PANTELIS TROMPOUKIS, “UROCORTIN EXPRESSION IN ENDOMETRIOSIS: A SYSTEMATIC REVIEW,” INTERNATIONAL JOURNAL OF FERTILITY AND STERILITY, vol. 13, no. 1, pp. 1–5, 2019, [Online]. Available: https://sid.ir/paper/306025/en

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