THE ASSOCIATION BETWEEN TNF-ALPHA GENE POLYMORPHISMSAND ENDOMETRIOSIS IN AN IRANIAN POPULATION

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Babaabasi Babak; AHANI ALI; SADEGHI FAEGHEH; BASHIZADEH FAKHAR HANIYEH; KHORRAM KHORSHID HAMID REZA

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Journal: International Journal of Fertility & Sterility Year:2019 | Volume:13 | Issue:1 Page(s): 6-11

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Title

THE ASSOCIATION BETWEEN TNF-ALPHA GENE POLYMORPHISMSAND ENDOMETRIOSIS IN AN IRANIAN POPULATION

Author(s)

Keywords

BODY MASS INDEX

ENDOMETRIOSIS

POLYMORPHISMS

RESTRICTION FRAGMENT LENGTH POLYMORPHISM

TNF-α

Abstract

Background: Tumor necrosis factor-alpha (TNF-α ) is an important cytokine in acute inflammatory response to infectivefactors. Based on investigation in different populations, it is thought that this response increases in patients with ENDOMETRIOSISdue to the presence of cytokines such as TNF-α . This study aimed to examine the association of four TNF-α POLYMORPHISMS, namely-238G/A,-308G/A,-857C/T and-863C/A, with susceptibility to ENDOMETRIOSIS in an Iranian population. Materials and Methods: We recruited 150 women with ENDOMETRIOSIS and 150 women without ENDOMETRIOSIS in thiscase-control study and collected 4 ml of blood from all subjects. After DNA extraction, the POLYMORPHISMS were genotypedby polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Results: The allele frequency of TNF-α-863C/A in the case and control groups showed a significant difference [oddsratios (OR)=0. 64, 95% confidence interval (CI)=0. 41-0. 99, P=0. 047] but the result is not significant when Adjustingfor multiple testing (P=0. 188). No significant difference in the allele frequencies of-238G/A (OR=1. 07, 95%CI=0. 51-2. 25, P=0. 862),-308G/A (OR=0. 79, 95% CI=0. 43-1. 45, P=0. 438) and-857C/T (OR=1. 03, 95% CI=0. 66-1. 61, P=0. 887) was observed. We adjusted all four polymorphism genotypes by age and BODY MASS INDEX (BMI), however, no significant difference was detected. There was an association between the case and control and BMI whenadjusting by age (OR=1. 082, 95% CI=1. 009-1. 162, P=0. 028). Conclusion: For the first time the association of the four POLYMORPHISMS in the promoter region of the TNF-α gene withendometriosis has been conducted in women of Iranian origin. The present research reveals the-863 A allele may playa role in incidence of ENDOMETRIOSIS among Iranian women. Development of ENDOMETRIOSIS among those people with-863 A allele seems low. According to the results, the current study indicates that there might be a correlation betweenBMI and progression of ENDOMETRIOSIS.

Cites

Endometriosis Classification and The Role of Tumor Necrosis Factor-Alpha Polymorphisms as A Therapeutic Target (Letter to The Editor)

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APA: Copy

Babaabasi, Babak, AHANI, ALI, SADEGHI, FAEGHEH, BASHIZADEH FAKHAR, HANIYEH, & KHORRAM KHORSHID, HAMID REZA. (2019). THE ASSOCIATION BETWEEN TNF-ALPHA GENE POLYMORPHISMSAND ENDOMETRIOSIS IN AN IRANIAN POPULATION. INTERNATIONAL JOURNAL OF FERTILITY AND STERILITY, 13(1), 6-11. SID. https://sid.ir/paper/306031/en

Vancouver: Copy

Babaabasi Babak, AHANI ALI, SADEGHI FAEGHEH, BASHIZADEH FAKHAR HANIYEH, KHORRAM KHORSHID HAMID REZA. THE ASSOCIATION BETWEEN TNF-ALPHA GENE POLYMORPHISMSAND ENDOMETRIOSIS IN AN IRANIAN POPULATION. INTERNATIONAL JOURNAL OF FERTILITY AND STERILITY[Internet]. 2019;13(1):6-11. Available from: https://sid.ir/paper/306031/en

IEEE: Copy

Babak Babaabasi, ALI AHANI, FAEGHEH SADEGHI, HANIYEH BASHIZADEH FAKHAR, and HAMID REZA KHORRAM KHORSHID, “THE ASSOCIATION BETWEEN TNF-ALPHA GENE POLYMORPHISMSAND ENDOMETRIOSIS IN AN IRANIAN POPULATION,” INTERNATIONAL JOURNAL OF FERTILITY AND STERILITY, vol. 13, no. 1, pp. 6–11, 2019, [Online]. Available: https://sid.ir/paper/306031/en

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