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Information Journal Paper

Title

PROTECTIVE EFFECT OF N-ACETYL CYSTEINE ON CHLORPYRIFOS-INDUCEDTESTICULAR TOXICITY IN MICE

Pages

  51-65

Abstract

 Background: CHLORPYRIFOS (CPF), an organophosphate pesticide, is widely used in farms in order to preserve cropsand fruits. Previous studies have shown that CPF exposure might cause chronic toxicity in male genital system. Thepresent study investigated the PROTECTIVE effect of N-Acetyl Cysteine (NAC), a potent antioxidant against testiculartoxicity of CPF in male mice. Materials and Methods: In this experimental study, 42 adult male mice were divided into seven groups, CPF low (0. 5mg/kg. b. w) and high (5 mg/kg. b. w) doses groups, NAC group (35 mg/kg. b. w), NAC+CPF 0/5 mg/kg. b. w, NAC+CPF5 mg/kg. b. w, dimethyl sulfoxide (DMSO, 0. 75% solution mg/kg. b. w) and control group. All treatment were doneintraperitoneally. Treatment was conducted for four consecutive weeks (five days each week). However NAC wasinjected to NAC+CPF groups five days before initiation of the treatment procedure. One week after the last injection, mice were sacrificed using anesthetic gas to evaluate alterations in testicular histology and SPERM parameters. Results: Seminiferous tubules area and diameter were significantly diminished in the group treated with 5 mg/kg CPF(P<0. 05). CPF also statistically reduced SPERM parameters (count and motility) and damaged SPERM morphology) atboth doses (P<0. 05). However, NAC significantly improved SPERMatogonia, SPERMatocytes, SPERMatid cell counts aswell as SPERM parameters in mice treated with both CPF concentrations (P<0. 05). Conclusion: According to our results, NAC may significantly ameliorate CPF-induced damages to SPERMatogonia, SPERMatocytes, SPERMatids cell counts and SPERM parameters.

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    APA: Copy

    KHERADMANDI, RASOUL, JORSARAEI, SEYED GHOLAM ALI, FEIZI, FARIDEH, MOGHADAMNIA, ALI AKBAR, & NEAMATI, NAHID. (2019). PROTECTIVE EFFECT OF N-ACETYL CYSTEINE ON CHLORPYRIFOS-INDUCEDTESTICULAR TOXICITY IN MICE. INTERNATIONAL JOURNAL OF FERTILITY AND STERILITY, 13(1), 51-65. SID. https://sid.ir/paper/306033/en

    Vancouver: Copy

    KHERADMANDI RASOUL, JORSARAEI SEYED GHOLAM ALI, FEIZI FARIDEH, MOGHADAMNIA ALI AKBAR, NEAMATI NAHID. PROTECTIVE EFFECT OF N-ACETYL CYSTEINE ON CHLORPYRIFOS-INDUCEDTESTICULAR TOXICITY IN MICE. INTERNATIONAL JOURNAL OF FERTILITY AND STERILITY[Internet]. 2019;13(1):51-65. Available from: https://sid.ir/paper/306033/en

    IEEE: Copy

    RASOUL KHERADMANDI, SEYED GHOLAM ALI JORSARAEI, FARIDEH FEIZI, ALI AKBAR MOGHADAMNIA, and NAHID NEAMATI, “PROTECTIVE EFFECT OF N-ACETYL CYSTEINE ON CHLORPYRIFOS-INDUCEDTESTICULAR TOXICITY IN MICE,” INTERNATIONAL JOURNAL OF FERTILITY AND STERILITY, vol. 13, no. 1, pp. 51–65, 2019, [Online]. Available: https://sid.ir/paper/306033/en

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